Membrane trafficking depends on transport vesicles and carriers docking and fusing with the
target organelle for the delivery of cargo. Membrane tethers and small guanosine …

Rab GTPases function as regulatory components of an evolutionarily conserved machinery
that mediates docking, priming, and fusion of vesicles with intracellular membranes. We …

Early endosomes are organelles that receive macromolecules and solutes from the
extracellular environment. The major function of early endosomes is to sort these cargos into …

Upon host cell infection, the obligate intracellular bacterium Coxiella burnetii resides and
multiplies within the C oxiella–C ontaining V acuole (CCV). The nascent CCV progresses …

The small GTPase Rab4 is implicated in endocytosis in all cell types, but also plays a
specific role in some regulated processes. To better understand the role of Rab4 in …

Immunotherapy has changed the treatment landscape for multiple cancer types. In the
recent decade, great progress has been made in immunotherapy, including immune …

Various growth factors and full-length cell surface receptors such as EGFR are translocated
from the cell surface to the nucleoplasm, baffling cell biologists to the mechanisms and …

Several intracellular pathogens arrest the phagosome maturation in the host cells to avoid
transport to lysosomes. In contrast, the Leishmania containing parasitophorous vacuole (PV) …

Over 50 years ago the lupus erythematosus (LE) cell phenomenon was described and this
was quickly followed by the introduction of the LE cell test and indirect immunofluorescence …

Here we present a detailed genetic analysis of let‐512/vps34 that encodes the
Caenorhabditis elegans homologue of the yeast phosphatidylinositol 3‐kinase Vps34p. LET …