J. Neurochem.(2011) 118, 475–489. Abstract Spontaneous and/or stimulated neural activity
of the nigrostriatal dopamine (DA) pathway makes amines run out from the neurons. This DA …

Dopamine transporter (DAT) trafficking was assessed by functional measurements of
dopamine uptake and by biotinylation of surface proteins followed by gel electrophoresis …

Pharmacological and behavioral studies indicate that binding of cocaine and the
amphetamines by the dopamine transporter (DAT) protein is principally responsible for …

The neuronal dopamine transporter (DAT) is a transmembrane transporter that clears DA
from the synaptic cleft. Knowledge of DAT functional group topography is a prerequisite for …

The different psychomotor‐stimulant effects of cocaine, GBR12909, and benztropine may
partially stem from their different molecular actions on the dopamine transporter (DAT). To …

Our previous work suggested that collapsing the Na+ gradient and membrane potential
converts the dopamine (DA) transporter (DAT) to an inward‐facing conformation with a …

The present study elucidated the role of aspartate 345, a residue conserved in the third
intracellular loop of all Na+/Cl--dependent neurotransmitter transporters, in conformational …

Changes in protease sensitivity of extracellular loop two (EL2) of the dopamine transporter
(DAT) during inhibitor and substrate binding were examined using trypsin proteolysis and …

Dopamine is a catecholamine neurotransmitter necessary for motor functions. Its deficiency
has been observed in several neurological disorders, but replacement of endogenous …

The benztropine analog N-(n-butyl)-3α-[bis (4′-fluorophenyl) methoxy]-tropane (JHW 007)
displays high affinity for the dopamine transporter (DAT), but unlike typical DAT ligands, has …