Our sense of touch emerges from an array of mechanosensory structures residing within the
fabric of our skin. These tactile end organ structures convert innocuous forces acting on the …

Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …

Itch triggers scratching, a behavioural defence mechanism that aids in the removal of
harmful irritants and parasites. Chemical itch is triggered by many endogenous and …

Neuropathic pain caused by a lesion or disease of the somatosensory nervous system is a
common chronic pain condition with major impact on quality of life. Examples include …

Nerve injury leads to chronic pain and exaggerated sensitivity to gentle touch (allodynia) as
well as a loss of sensation in the areas in which injured and non-injured nerves come …

Mechanotransduction couples mechanical stimulation with ion flux, which is critical for
normal biological processes involved in neuronal cell development, pain sensation, and red …

Distinct types of dorsal root ganglion sensory neurons may have unique contributions to
chronic pain. Identification of primate sensory neuron types is critical for understanding the …

The brush of a feather and a pinprick are perceived as distinct sensations because they are
detected by discrete cutaneous sensory neurons. Inflammation or nerve injury can disrupt …

Pain results from the activation of a subset of sensory neurones termed nociceptors and has
evolved as a “detect and protect” mechanism. However, lesion or disease in the sensory …

Dorsal root ganglion (DRG) sensory neuron subtypes defined by their in vivo properties
display distinct intrinsic electrical properties. We used bulk RNA sequencing of genetically …