Parkinson's disease
Parkinson's disease is a recognisable clinical syndrome with a range of causes and clinical
presentations. Parkinson's disease represents a fast-growing neurodegenerative condition; …
presentations. Parkinson's disease represents a fast-growing neurodegenerative condition; …
Adaptive deep brain stimulation: From experimental evidence toward practical implementation
WJ Neumann, R Gilron, S Little… - Movement …, 2023 - Wiley Online Library
Closed‐loop adaptive deep brain stimulation (aDBS) can deliver individualized therapy at
an unprecedented temporal precision for neurological disorders. This has the potential to …
an unprecedented temporal precision for neurological disorders. This has the potential to …
Beta oscillations in working memory, executive control of movement and thought, and sensorimotor function
Beta oscillations (∼ 13 to 30 Hz) have been observed during many perceptual, cognitive,
and motor processes in a plethora of brain recording studies. Although the function of beta …
and motor processes in a plethora of brain recording studies. Although the function of beta …
Pathological pallidal beta activity in Parkinson's disease is sustained during sleep and associated with sleep disturbance
Parkinson's disease (PD) is associated with excessive beta activity in the basal ganglia.
Brain sensing implants aim to leverage this biomarker for demand-dependent adaptive …
Brain sensing implants aim to leverage this biomarker for demand-dependent adaptive …
Deep brain stimulation in movement disorders: from experimental surgery to evidence‐based therapy
Deep brain stimulation (DBS) of 3 different targets is the most important therapeutic
innovation of the past 30 years for patients with fluctuating Parkinson's disease (PD) …
innovation of the past 30 years for patients with fluctuating Parkinson's disease (PD) …
Insights and opportunities for deep brain stimulation as a brain circuit intervention
Deep brain stimulation (DBS) is an effective treatment and has provided unique insights into
the dynamic circuit architecture of brain disorders. This Review illustrates our current …
the dynamic circuit architecture of brain disorders. This Review illustrates our current …
Neurophysiological mechanisms of deep brain stimulation across spatiotemporal resolutions
WJ Neumann, LA Steiner, L Milosevic - Brain, 2023 - academic.oup.com
Deep brain stimulation is a neuromodulatory treatment for managing the symptoms of
Parkinson's disease and other neurological and psychiatric disorders. Electrodes are …
Parkinson's disease and other neurological and psychiatric disorders. Electrodes are …
Human motor cortical beta bursts relate to movement planning and response errors
Motor cortical beta activity (13–30 Hz) is a hallmark signature of healthy and pathological
movement, but its behavioural relevance remains unclear. Using high-precision …
movement, but its behavioural relevance remains unclear. Using high-precision …
Driving motor cortex oscillations modulates bradykinesia in Parkinson's disease
A Guerra, D Colella, M Giangrosso, A Cannavacciuolo… - Brain, 2022 - academic.oup.com
In patients with Parkinson's disease, beta (β) and gamma (γ) oscillations are altered in the
basal ganglia, and this abnormality contributes to the pathophysiology of bradykinesia …
basal ganglia, and this abnormality contributes to the pathophysiology of bradykinesia …