Parkinson's disease

BR Bloem, MS Okun, C Klein - The Lancet, 2021 - thelancet.com
Parkinson's disease is a recognisable clinical syndrome with a range of causes and clinical
presentations. Parkinson's disease represents a fast-growing neurodegenerative condition; …

Adaptive deep brain stimulation: From experimental evidence toward practical implementation

WJ Neumann, R Gilron, S Little… - Movement …, 2023 - Wiley Online Library
Closed‐loop adaptive deep brain stimulation (aDBS) can deliver individualized therapy at
an unprecedented temporal precision for neurological disorders. This has the potential to …

Beta oscillations in working memory, executive control of movement and thought, and sensorimotor function

R Schmidt, MH Ruiz, BE Kilavik… - Journal of …, 2019 - Soc Neuroscience
Beta oscillations (∼ 13 to 30 Hz) have been observed during many perceptual, cognitive,
and motor processes in a plethora of brain recording studies. Although the function of beta …

Pathological pallidal beta activity in Parkinson's disease is sustained during sleep and associated with sleep disturbance

Z Yin, R Ma, Q An, Y Xu, Y Gan, G Zhu, Y Jiang… - Nature …, 2023 - nature.com
Parkinson's disease (PD) is associated with excessive beta activity in the basal ganglia.
Brain sensing implants aim to leverage this biomarker for demand-dependent adaptive …

Evolving concepts on bradykinesia

M Bologna, G Paparella, A Fasano, M Hallett… - Brain, 2020 - academic.oup.com
Bradykinesia is one of the cardinal motor symptoms of Parkinson's disease and other
parkinsonisms. The various clinical aspects related to bradykinesia and the …

Deep brain stimulation in movement disorders: from experimental surgery to evidence‐based therapy

P Krack, J Volkmann, G Tinkhauser… - Movement …, 2019 - Wiley Online Library
Deep brain stimulation (DBS) of 3 different targets is the most important therapeutic
innovation of the past 30 years for patients with fluctuating Parkinson's disease (PD) …

Insights and opportunities for deep brain stimulation as a brain circuit intervention

WJ Neumann, A Horn, AA Kühn - Trends in Neurosciences, 2023 - cell.com
Deep brain stimulation (DBS) is an effective treatment and has provided unique insights into
the dynamic circuit architecture of brain disorders. This Review illustrates our current …

Neurophysiological mechanisms of deep brain stimulation across spatiotemporal resolutions

WJ Neumann, LA Steiner, L Milosevic - Brain, 2023 - academic.oup.com
Deep brain stimulation is a neuromodulatory treatment for managing the symptoms of
Parkinson's disease and other neurological and psychiatric disorders. Electrodes are …

Human motor cortical beta bursts relate to movement planning and response errors

S Little, J Bonaiuto, G Barnes, S Bestmann - PLoS biology, 2019 - journals.plos.org
Motor cortical beta activity (13–30 Hz) is a hallmark signature of healthy and pathological
movement, but its behavioural relevance remains unclear. Using high-precision …

Driving motor cortex oscillations modulates bradykinesia in Parkinson's disease

A Guerra, D Colella, M Giangrosso, A Cannavacciuolo… - Brain, 2022 - academic.oup.com
In patients with Parkinson's disease, beta (β) and gamma (γ) oscillations are altered in the
basal ganglia, and this abnormality contributes to the pathophysiology of bradykinesia …