Middle age has historically been an understudied period of life compared to older age, when
cognitive and brain health decline are most pronounced, but the scope for intervention may …

Background A growing body of literature examines the relationship between peripheral
immune function and Alzheimer's Disease (AD) in human populations. Our living systematic …

There has been an explosion of research into biofluid (blood, cerebrospinal fluid, CSF)-
based protein biomarkers in traumatic brain injury (TBI) over the past decade. The …

Cerebral amyloid angiopathy (CAA) is characterized by amyloid β (Aβ) accumulation in the
blood vessels and is associated with cognitive impairment in Alzheimer's disease (AD). The …

The advent of proteomics offers an unprecedented opportunity to predict dementia onset.
We examined this in data from 52,645 adults without dementia in the UK Biobank, with 1,417 …

Alzheimer's disease (AD) is currently defined at the research level by the aggregation of
amyloid-β (Aβ) and tau proteins in brain. While biofluid biomarkers are available to measure …

Alzheimer's disease has an increasing prevalence in the population world-wide, yet current
diagnostic methods based on recommended biomarkers are only available in specialized …

Resveratrol, a naturally occurring polyphenol that activates sirtuin 1 (SIRT1), has been
shown to reduce overall levels of matrix metalloprotease9 (MMP9) in cerebrospinal fluid …

Abstract Machine learning models are increasingly being used to estimate “brain age” from
neuroimaging data. The gap between chronological age and the estimated brain age gap …

Background The endoplasmic reticulum (ER) transmembrane chaperones DNAJB12 (B12)
and DNAJB14 (B14) are cofactors that cooperate with cytosolic Heat Shock-70 protein …