Astrocytes in the pathophysiology of neuroinfection

R Zorec, A Verkhratsky - Essays in biochemistry, 2023 - portlandpress.com
Key homeostasis providing cells in the central nervous system (CNS) are astrocytes, which
belong to the class of cells known as atroglia, a highly heterogeneous type of neuroglia and …

[HTML][HTML] Hydroxytyrosol and Arginine as Antioxidant, Anti-Inflammatory and Immunostimulant Dietary Supplements for COVID-19 and Long COVID

JM Pérez de la Lastra, CM Curieses Andrés… - Foods, 2023 - mdpi.com
Phytochemicals from plant extracts are becoming increasingly popular in the world of food
science and technology because they have positive effects on human health. In particular …

[HTML][HTML] Plasma metabolomic characterization of SARS-CoV-2 Omicron infection

X Li, Y Liu, G Xu, Y Xie, X Wang, J Wu, H Chen - Cell Death & Disease, 2023 - nature.com
Omicron variants of SARS-CoV-2 have spread rapidly worldwide; however, most infected
patients have mild or no symptoms. This study aimed to understand the host response to …

Redox regulation and metabolic dependency of Zika virus replication: Inhibition by Nrf2-antioxidant response and NAD (H) antimetabolites

BR Sahoo, AA Crook, A Pattnaik… - Journal of …, 2023 - Am Soc Microbiol
Viral infections alter host cell metabolism and homeostasis; however, the mechanisms that
regulate these processes have only begun to be elucidated. We report here that Zika virus …

[HTML][HTML] Oxidative damage and post-COVID syndrome: a cross-sectional study in a cohort of italian workers

A Stufano, C Isgrò, LL Palese, P Caretta… - International Journal of …, 2023 - mdpi.com
In addition to the acute symptoms after infection, patients and society are also being
challenged by the long-term effects of COVID-19, known as long COVID. Oxidative stress, as …

Prior metabolite extraction fully preserves RNAseq quality and enables integrative multi-'omics analysis of the liver metabolic response to viral infection

ZB Madaj, MS Dahabieh, V Kamalumpundi… - RNA biology, 2023 - Taylor & Francis
Here, we provide an in-depth analysis of the usefulness of single-sample metabolite/RNA
extraction for multi-'omics readout. Using pulverized frozen livers of mice injected with …

An immunocompetent Mongolian gerbil model for hepatitis E virus genotype 1 infection

T Liu, Q He, X Yang, Y Li, D Yuan, Q Lu, T Tang… - Gastroenterology, 2024 - Elsevier
Background and Aims Hepatitis E virus (HEV), primarily genotype 1 (HEV-1), causes
approximately 20.1 million infections, 44,000 deaths, and 3000 stillbirths annually. Current …

[PDF][PDF] Mitochondrial dysfunction, lipids metabolism, and amino acid biosynthesis are key pathways for COVID-19 recovery

A Sánchez, G García-Pardo, F Gómez-Bertomeu… - Iscience, 2023 - cell.com
The metabolic alterations caused by SARS-CoV-2 infection reflect disease progression. To
analyze molecules involved in these metabolic changes, a multiomics study was performed …

[HTML][HTML] The Influence of Metabolism on Immune Response: A Journey to Understand Immunometabolism in the Context of Viral Infection

D El Safadi, A Paulo-Ramos, M Hoareau, M Roche… - Viruses, 2023 - mdpi.com
In recent years, the emergence of the concept of immunometabolism has shed light on the
pivotal role that cellular metabolism plays in both the activation of immune cells and the …

Early Initiation of Antiretroviral Therapy Preserves the Metabolic Function of CD4+ T Cells in Subtype C Human Immunodeficiency Virus 1 Infection

KK Naidoo, AJ Highton, OO Baiyegunhi… - The Journal of …, 2024 - academic.oup.com
Background Immune dysfunction often persists in people living with human
immunodeficiency virus (HIV) who are on antiretroviral therapy (ART), clinically manifesting …