The pharmaceutical development of amorphous solid dispersions (ASDs) by hot-melt
extrusion (HME) is briefly reviewed. A systematic step-by-step approach is presented, where …

Ellagic acid (EA) is a polyphenolic active compound with antimalarial and other promising
therapeutic activities. However, its solubility and its permeability are both low (BCS IV) …

For the last 40 years, praziquantel has been the standard treatment for schistosomiasis, a
neglected parasitic disease affecting more than 250 million people worldwide. However …

The present study aimed to analyze how the printing process affects the final state of a
printed pharmaceutical product and to establish prediction models for post-printing …

As a biopharmaceutical classification system Class IV drug, lopinavir (LPV) shows relatively
poor water solubility and permeation in vivo. In the study, we developed novel solid …

Design of Experiments (DoE) is a statistical tool used to plan and optimize experiments and
is seen as a quality technology to achieve products excellence. Among the experimental …

It is well-known that plenty of active pharmaceutical ingredients (API) inherently possess an
unpleasant taste, which influences the acceptance of patients, especially children …

One of the challenges in developing three-dimensional printed medicines is related to their
stability due to the manufacturing conditions involving high temperatures. This work …

This study aimed to mask fluconazole (FLU) taste and improve its rheological properties by
an efficient process of cyclodextrin complexation. For this, hot-melt extrusion (HME) was …

The palatability of medications is an essential factor for children's adherence to drug
treatment. Several methods for drug taste assessment have been developed. The aim of this …