Hypertension, a multifactorial disorder resulting from the interplay between genetic
predisposition and environmental risk factors, affects≈ 30% of adults. Emerging evidence …

Non-alcoholic fatty liver disease (NAFLD) has become the fastest growing chronic liver
disease, with a prevalence of up to 25% worldwide. Individuals with NAFLD have a high risk …

Toll-interacting protein (TOLLIP) is a ubiquitous intracellular adaptor protein involved in
multiple intracellular signaling pathways. It plays a key role in mediating inflammatory …

A polymorphism causing deficiencies in Toll-interacting protein (TOLLIP), an inhibitory
adaptor protein affecting endosomal trafficking, is associated with increased tuberculosis …

The activation of signaling pathways induced by Toll-like receptor (TLR) has been
demonstrated to play essential roles in multiple liver diseases. Toll-interacting protein …

Aims: The proliferation and migration of vascular smooth muscle cells (VSMCs) play vital
roles in the pathological process of neointima formation after vascular injury. Galangin, an …

Immune cascade is one of major factors leading to cardiac dysfunction after burn injury.
TLRs are a class of pattern-recognition receptors (PRRs) that initiate the innate immune …

Although autologous vein grafting is essential, the high vein failure rate and specific clinical
interventions are not clear, so a potential treatment is critically needed; thus, complex …

Vascular smooth muscle cell (VSMC) migration contributes to vascular remodeling after
injury, whereas oxidative stress generated through dysfunctional redox homeostasis …

Aetiology of the establishment of Leishmania donovani infection in its host is still not well
understood. Host immune system plays a key role during pathogen entry, survival and …