Chemical carcinogenesis involves a complex series of events, the earliest of which typically
include DNA damage and the fixation of DNA mutations. Sophisticated new techniques have …

Tobacco smoking causes not only lung cancer but also cancer of the oral and nasal cavities,
oesophagus, larynx, pharynx, pancreas, liver, kidney, stomach, urinary tract and cervix …

Endogenous DNA adducts may contribute to the etiology of human genetic disease and
cancer. One potential source of endogenous DNA adducts is lipid peroxidation, which …

Several epidemiological studies have indicated that female tobacco smokers may be at
higher risk of lung cancer than males. In a study of lung cancer cases, we have found that …

The levels of aromatic/hydrophobic DNA adducts were analyzed in normal lung tissue from
63 lung cancer patients and examined in relation to exposure and genetic factors. Adduct …

BACKGROUND: DNA adducts formed as a consequence of exposure to tobacco smoke may
be involved in carcinogenesis, and their presence may indicate a high risk of lung cancer …

Benzo [a] pyrene diol epoxide (BPDE)–DNA adducts are involved in the induction of p53
mutations and probably in the causation of human lung cancer associated with cigarette …

In this matched case-control study nested within the prospective Physicians' Health Study,
we evaluated whether DNA damage in blood samples collected at enrollment significantly …

Although cigarette smoking is the dominant risk factor for several epithelial cancers, only a
small fraction of individuals with tobacco exposure develop cancer. The underlying …

Environmental, occupational, and recreational exposures to carcinogens contribute to
cancer risk in humans. Cancer formation is a multistage process involving tumor initiation …