Mitochondrial dysfunction has been regarded as a hallmark of diabetic cardiomyopathy. In
addition to their canonical metabolic actions, mitochondria influence various other aspects of …

A large body of evidence indicates the existence of a complex pathophysiological
relationship between cardiovascular diseases and cancer. Mitochondria are crucial …

Myocardial ischemia/reperfusion (I/R) injury is a classic type of cardiovascular disease
characterized by injury to cardiomyocytes leading to various forms of cell death. It is believed …

Mitophagy preserves microvascular structure and function during myocardial
ischemia/reperfusion (I/R) injury. Empagliflozin, an anti-diabetes drug, may also protect …

Mitochondrial dysfunction is a fundamental challenge in septic cardiomyopathy. Mitophagy
and the mitochondrial unfolded protein response (UPR mt) are the predominant stress …

Background Inflammation and immune dysfunction with classically activated macrophages
(M1) infiltration are important mechanisms in the progression of atherosclerosis (AS) …

Necroptosis is the major cause of death in alveolar epithelial cells (AECs) during acute lung
injury (ALI). Here, we report a previously unrecognized mechanism for necroptosis. We …

In the present study, we used lipopolysaccharide‐(LPS‐) stimulated H9C2 cardiomyocytes
to investigate whether irisin treatment attenuates septic cardiomyopathy via Fundc1‐related …

Diabetic patients are frequently affected by coronary microvascular dysfunction (CMD), a
condition consisting of a combination of altered vasomotion and long-term structural change …

Ferroptosis, a form of regulated cell death, plays an important role in acute kidney injury
(AKI). Previous studies have shown that prolyl hydroxylase domain protein (PHD) inhibitors …