Regulatory T cells (Treg) are well-known for their immune regulatory potential and are
essential for maintaining immune homeostasis. The rationale of Treg-based immunotherapy …

Bladder cancer—the tenth most frequent cancer worldwide—has a heterogeneous natural
history and clinical behaviour. The predominant histological subtype, urothelial bladder …

Objective: To explore the role of phosphatidylinositol-3-kinase/protein kinase B and alpha
serine/threonine protein kinase PI3K/PKB (also known as PI3K/Akt) signaling pathway in …

The SARS-CoV-2 virus has caused a worldwide COVID-19 pandemic. In less than a year
and a half, more than 200 million people have been infected and more than four million …

Regulatory T cells overexpressing SPARC (secreted protein acidic and cysteine
rich)(Sparchigh Tregs) can help repair infarct tissues after acute myocardial infarction (AMI) …

Systemic lupus erythematosus (SLE) is a typical autoimmune disease characterized by
multiorgan involvement and marked variability in clinical presentation. SLE pathogenesis …

Introduction Regulatory T cell (Treg) therapy has been demonstrated to facilitate long-term
allograft survival in preclinical models of transplantation and may permit reduction of …

Background The present study aimed to determine the functional role of miR-206 in T helper
17 (Th17)/regulatory T (Treg) cell differentiation during the development of osteoarthritis …

Current immunosuppressive (IS) regimens used to prevent organ allograft rejection have
well-recognized side effects, that include enhanced risk of infection and certain types of …

A successful pregnancy requires the maternal immune system to accept a fetus expressing
allogeneic paternal antigens and provide competent responses to infections. Accordingly …