Introduction A new era of treatment for adults with treatment-resistant depression (TRD),
which involves psychedelic substances, is dawning. Emerging evidence indicates that …

Proactively predicting antidepressant treatment response before medication failures is
crucial, as it reduces unsuccessful attempts and facilitates the development of personalized …

The effectiveness of the esketamine nasal spray (ESK-NS) for treatment-resistant
depression (TRD) has been confirmed by real-world studies. Available evidence derived …

Background Unipolar and bipolar depression present treatment challenges, with patients
sometimes showing limited or no response to standard medications. Ketamine and its …

This study focuses on a nature-based group treatment (Flow with Nature [FWN] treatment)
for working-age adults diagnosed with clinical depression. We searched for different …

Approximately 1 in 20 Canadians are diagnosed with it each year, and it is the second
highest cause of disability worldwide. 1 Nonresponse to treatment is common, with response …

This systematic review and meta-analysis aimed to assess the efficacy and acceptability of S-
adenosyl-L-methionine (SAMe) in treating depression. We conducted a comprehensive …

Background Over the last two decades, ketamine has gained significant interest in
psychiatry as a potential treatment for major depressive disorder (MDD), especially in …

Background About one third of patients with depression are in a condition that can be
termed as “difficult-to-treat”. Some evidence suggests that difficult-to-treat depression is …

It has recently been recommended that treatment resistant depression be reconceptualized
and renamed as difficult to treat depression (DTD). A consensus statement by an expert …