ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

Its increasing incidence has led stroke to be the second leading cause of death worldwide.
Despite significant advances in recanalization strategies, patients are still at risk for …

Ischemic stroke (IS) is one of the most common causes of disability and death. Thrombolysis
and neuroprotection are two current major therapeutic strategies to overcome ischemic and …

Turmeric (Curcuma longa L.) is a spice utilized widely in India, China, and Southeast Asia as
an aromatic stimulant, a food preservative, and coloring material. The commonly used …

Oxidative stress and a series of excessive inflammatory responses are major obstacles for
neurological functional recovery after ischemic stroke. Effective noninvasive anti …

Background Pyroptosis mediated by NLRP3 inflammasome plays a critical role in the
pathogenesis of cerebral ischemia-reperfusion (I/R) injury. Mounting evidences have …

Purpose Stroke is a disease associated with high mortality. Many inflammatory indicators
such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte …

Ischemic stroke caused by intracranial vascular occlusion has become increasingly
prevalent with considerable mortality and disability, which gravely burdens the global …

The blood-brain barrier (BBB) is a dynamic structure that protects the brain from harmful
blood-borne, endogenous and exogenous substances and maintains the homeostatic …

Hemorrhagic transformation (HT) is a common complication in patients with acute ischemic
stroke. It occurs when peripheral blood extravasates across a disrupted blood brain barrier …