[HTML][HTML] A novel BRD4 inhibitor suppresses osteoclastogenesis and ovariectomized osteoporosis by blocking RANKL-mediated MAPK and NF-κB pathways

Y Liu, W Liu, Z Yu, Y Zhang, Y Li, D Xie, G Xie… - Cell Death & …, 2021 - nature.com
Abstract Bromodomain-containing protein 4 (BRD4) has emerged as a promising treatment
target for bone-related disorders.(+)-JQ1, a thienotriazolodiazepine compound, has been …

[HTML][HTML] Piperlongumine inhibits titanium particles-induced osteolysis, osteoclast formation, and RANKL-induced signaling pathways

X Liu, L Diao, Y Zhang, X Yang, J Zhou, Y Mao… - International journal of …, 2022 - mdpi.com
Wear particle-induced aseptic loosening is the most common complication of total joint
arthroplasty (TJA). Excessive osteoclast formation and bone resorptive activation have been …

[HTML][HTML] MicroRNA‑21 serves an important role during PAOO‑facilitated orthodontic tooth movement

Y Zhang, Y Tian, X Yang, Z Zhao… - Molecular …, 2020 - spandidos-publications.com
Periodontal accelerate osteogenesis orthodontics (PAOO) is an extension of described
techniques that surgically alter the alveolar bone; however, the specific mechanism …

Simvastatin promotes murine osteoclasts apoptosis in vitro through NFATc1 pathway

D Yu, D Zhao, D Yang, G Yang - Nan Fang yi ke da xue xue bao …, 2019 - europepmc.org
OBJECTIVE: To explore the mechanism by which simvastatin (SIM) regulates osteoclast
apoptosis. METHODS: Murine macrophage RAW264. 7 cells were divided into 5 groups …

Magnesium supplementation reduces cigarette smoke–associated cell damage in 3D bone fracture healing model

W Weng - 2022 - ub01.uni-tuebingen.de
It is well established that CS has an adverse impact on bone homeostasis, contributing to
increased risk of fragility fractures and impaired fracture healing. CS is capable of …

[HTML][HTML] 辛伐他汀通过NFATc1 通路促进破骨细胞的凋亡

于冬冬, 赵丹阳, 杨鸫祥, 杨关林 - Journal of Southern Medical …, 2019 - ncbi.nlm.nih.gov
辛伐他汀通过NFATc1通路促进破骨细胞的凋亡- PMC Back to Top Skip to main content NIH
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