Reactive hyperemia is a well-established technique for noninvasive assessment of
peripheral microvascular function and a predictor of all-cause and cardiovascular morbidity …

The discovery of nitric oxide (NO) as a crucial endothe-lium-derived molecule for vascular
relaxation and the recognition of the endothelium as more than a passive interface between …

The mammalian genome encodes 28 distinct members of the transient receptor potential
(TRP) superfamily of cation channels, which exhibit varying degrees of selectivity for …

Hydrogen sulfide (H2S) has recently emerged as a mammalian gaseous messenger
molecule, akin to nitric oxide and carbon monoxide. H2S is predominantly formed from Cys …

The anatomy and physiology of the microcirculation in human skin are complex. Normal
cutaneous microcirculation is organized in two parallel plexuses with capillary loops …

The endothelium exerts multiple actions involving regulation of vascular permeability and
tone, coagulation and fibrinolysis, inflammatory and immunological reactions and cell …

Major features of the transcellular signaling mechanism responsible for endothelium-
dependent regulation of vascular smooth muscle tone are unresolved. We identified local …

The mineralocorticoid receptor (MR) and its ligand aldosterone are the principal modulators
of hormone-regulated renal sodium reabsorption. In addition to the kidney, there are several …

Inflammation is a complex and potentially life-threatening condition that involves the
participation of a variety of chemical mediators, signaling pathways, and cell types. The …

Central serous chorioretinopathy (CSCR) is a vision-threatening eye disease with no
validated treatment and unknown pathogeny. In CSCR, dilation and leakage of choroid …