The state of complement in COVID-19
Hyperactivation of the complement and coagulation systems is recognized as part of the
clinical syndrome of COVID-19. Here we review systemic complement activation and local …
clinical syndrome of COVID-19. Here we review systemic complement activation and local …
Extracellular vesicles in the pathogenesis and treatment of acute lung injury
Q Hu, S Zhang, Y Yang, JQ Yao, WF Tang… - Military Medical …, 2022 - Springer
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common life-
threatening lung diseases associated with acute and severe inflammation. Both have high …
threatening lung diseases associated with acute and severe inflammation. Both have high …
Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral proteins bind to host
mitochondrial proteins, likely inhibiting oxidative phosphorylation (OXPHOS) and stimulating …
mitochondrial proteins, likely inhibiting oxidative phosphorylation (OXPHOS) and stimulating …
[HTML][HTML] SARS-CoV-2 spike promotes inflammation and apoptosis through autophagy by ROS-suppressed PI3K/AKT/mTOR signaling
F Li, J Li, PH Wang, N Yang, J Huang, J Ou, T Xu… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Background Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection-
induced inflammatory responses are largely responsible for the death of novel coronavirus …
induced inflammatory responses are largely responsible for the death of novel coronavirus …
SARS-CoV-2 Infects Endothelial Cells In Vivo and In Vitro
SARS-CoV-2 infection can cause fatal inflammatory lung pathology, including thrombosis
and increased pulmonary vascular permeability leading to edema and hemorrhage. In …
and increased pulmonary vascular permeability leading to edema and hemorrhage. In …
A comprehensive SARS-CoV-2 and COVID-19 review, Part 1: Intracellular overdrive for SARS-CoV-2 infection
DA Jamison Jr, S Anand Narayanan… - European Journal of …, 2022 - nature.com
COVID-19, the disease caused by SARS-CoV-2, has claimed approximately 5 million lives
and 257 million cases reported globally. This virus and disease have significantly affected …
and 257 million cases reported globally. This virus and disease have significantly affected …
Jingfang Granules (荆防颗粒) alleviates bleomycin-induced acute lung injury through regulating PI3K/Akt/mTOR signaling pathway
X Sun, H Xiang, Z Liu, H Xiao, X Li, W Gong… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Acute lung injury is a kind of clinical emergency severe
syndrome which might trigger acute respiratory distress syndrome. Jingfang Granules …
syndrome which might trigger acute respiratory distress syndrome. Jingfang Granules …
Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2
B Xia, X Pan, RH Luo, X Shen, S Li, Y Wang, X Zuo… - Cell discovery, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global
pandemic. Antibody resistance dampens neutralizing antibody therapy and threatens …
pandemic. Antibody resistance dampens neutralizing antibody therapy and threatens …
Natural products, alone or in combination with FDA-approved drugs, to treat COVID-19 and lung cancer
L Yang, Z Wang - Biomedicines, 2021 - mdpi.com
As a public health emergency of international concern, the highly contagious coronavirus
disease 2019 (COVID-19) pandemic has been identified as a severe threat to the lives of …
disease 2019 (COVID-19) pandemic has been identified as a severe threat to the lives of …
The role of epithelial damage in the pulmonary immune response
Pulmonary epithelial cells are widely considered to be the first line of defence in the lung
and are responsible for coordinating the innate immune response to injury and subsequent …
and are responsible for coordinating the innate immune response to injury and subsequent …