The state of complement in COVID-19

B Afzali, M Noris, BN Lambrecht… - Nature Reviews …, 2022 - nature.com
Hyperactivation of the complement and coagulation systems is recognized as part of the
clinical syndrome of COVID-19. Here we review systemic complement activation and local …

Extracellular vesicles in the pathogenesis and treatment of acute lung injury

Q Hu, S Zhang, Y Yang, JQ Yao, WF Tang… - Military Medical …, 2022 - Springer
Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are common life-
threatening lung diseases associated with acute and severe inflammation. Both have high …

Core mitochondrial genes are down-regulated during SARS-CoV-2 infection of rodent and human hosts

JW Guarnieri, JM Dybas, H Fazelinia, MS Kim… - Science translational …, 2023 - science.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral proteins bind to host
mitochondrial proteins, likely inhibiting oxidative phosphorylation (OXPHOS) and stimulating …

[HTML][HTML] SARS-CoV-2 spike promotes inflammation and apoptosis through autophagy by ROS-suppressed PI3K/AKT/mTOR signaling

F Li, J Li, PH Wang, N Yang, J Huang, J Ou, T Xu… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Background Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection-
induced inflammatory responses are largely responsible for the death of novel coronavirus …

SARS-CoV-2 Infects Endothelial Cells In Vivo and In Vitro

F Liu, K Han, R Blair, K Kenst, Z Qin, B Upcin… - Frontiers in cellular …, 2021 - frontiersin.org
SARS-CoV-2 infection can cause fatal inflammatory lung pathology, including thrombosis
and increased pulmonary vascular permeability leading to edema and hemorrhage. In …

A comprehensive SARS-CoV-2 and COVID-19 review, Part 1: Intracellular overdrive for SARS-CoV-2 infection

DA Jamison Jr, S Anand Narayanan… - European Journal of …, 2022 - nature.com
COVID-19, the disease caused by SARS-CoV-2, has claimed approximately 5 million lives
and 257 million cases reported globally. This virus and disease have significantly affected …

Jingfang Granules (荆防颗粒) alleviates bleomycin-induced acute lung injury through regulating PI3K/Akt/mTOR signaling pathway

X Sun, H Xiang, Z Liu, H Xiao, X Li, W Gong… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance Acute lung injury is a kind of clinical emergency severe
syndrome which might trigger acute respiratory distress syndrome. Jingfang Granules …

Extracellular vesicles mediate antibody-resistant transmission of SARS-CoV-2

B Xia, X Pan, RH Luo, X Shen, S Li, Y Wang, X Zuo… - Cell discovery, 2023 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global
pandemic. Antibody resistance dampens neutralizing antibody therapy and threatens …

Natural products, alone or in combination with FDA-approved drugs, to treat COVID-19 and lung cancer

L Yang, Z Wang - Biomedicines, 2021 - mdpi.com
As a public health emergency of international concern, the highly contagious coronavirus
disease 2019 (COVID-19) pandemic has been identified as a severe threat to the lives of …

The role of epithelial damage in the pulmonary immune response

RA Burgoyne, AJ Fisher, LA Borthwick - Cells, 2021 - mdpi.com
Pulmonary epithelial cells are widely considered to be the first line of defence in the lung
and are responsible for coordinating the innate immune response to injury and subsequent …