BACKGROUND: Drug-resistant depression is a major therapeutic issue in psychiatry and
the development of non-drug therapies that treat drug-resistant depression is required …

Nearly all psychiatric disorders present with circadian disruption, such as abnormalities in
the timing of the sleep-wake cycle, core body temperature rhythms, and melatonin and …

Total sleep deprivation (TSD) leads to an immediate amelioration of depressed mood in
approximately 70% of patients with the melancholic subtype of depression. The clinical utility …

Ketamine, a drug with rapid antidepressant effects and well-described effects on slow wave
sleep (SWS), is a useful intervention for investigating sleep–wake mechanisms involved in …

В современной медицине все меньше остается нозологических единиц, которые,
несмотря на самый современный подход и востребованность их изучения, до сих пор …

The complaint of excessive daytime sleepiness (EDS), commonly encountered in clinical
practice, may arise from a variety of psychiatric disorders, most importantly depression. Even …

Disturbances of circadian rhythms are associated with many types of mood disorders;
however, it is unknown whether a dysfunctional circadian pacemaker can be the primary …

In the last 30 years, it has been convincingly demonstrated that sleep in major depression is
characterized by disturbances of sleep continuity, a reduction of slow wave sleep, a …

Until recently, neuroscience has given sleep research and discovery of better treatments of
sleep disturbances little attention, despite the fact that disturbed sleep has overwhelming …

Recent European studies suggested that sleep phase advance (SPA) could sustain the
effects of total sleep deprivation (TSD) both with or without a combined antidepressant drug …