Unstimulated production of interleukine-6 (IL-6) is known to be enhanced in patients affected
by a major depressive episode. Recent studies supported a role for basal IL-6 levels in …

Chronobiological therapies for mood disorders include manipulations of the sleep–wake
cycle such as sleep deprivation and sleep phase advance and the controlled exposure to …

In spite of recent progress in the pharmacotherapy of depression major issues are still
unresolved. These include the non-response rate of approximately 30% to conventional …

Objective: Disturbed sleep is typical for most depressed patients and complaints about
disordered sleep are the hallmarks of the disorder. Polysomnographic sleep research has …

Chronotherapeutics refers to treatments based on the principles of circadian rhythm
organization and sleep physiology, which control the exposure to environmental stimuli that …

The goals of the current study were to evaluate whether a single dose of fluoxetine causes
qualitatively different changes in sleep architecture and NREM sleep EEG than subchronic …

Deficiencies in brain orexins and components of mitogen activated protein kinase (MAPK)
signaling pathway have been reported in either human depression or animal model of …

The fast but short-lasting improvement of depressive symptoms by sleep deprivation (SD) in
about 60% of patients with a major depressive disorder is well established, but the …

Introduction The aim was to assess the efficacy of total sleep deprivation (TSD) with sleep
phase advance (SPA) in treatment-resistant depression (TRD) and associated biochemical …

BACKGROUND: Most antidepressant medications in current use have several
disadvantages: a delayed therapeutic effect, side effects, stigmatization and concerns about …