Abstract Post-Operative Cognitive Dysfunction (POCD) is a highly prevalent condition with
significant clinical, social and financial impacts for patients and their communities. The …

Postoperative cognitive dysfunction (POCD) is a prevalent clinical entity following surgery
and is characterized by declined neurocognitive function. Neuroinflammation mediated by …

Background Elderly patients are more likely to suffer from postoperative cognitive
dysfunction (POCD) after surgery and anesthesia. Except for declined organ function, the …

Blood–brain barrier (BBB) dysfunction, eg, increase in BBB permeability, has been reported
to contribute to cognitive impairment. However, the effects of anesthesia and surgery on BBB …

Obesity is a major health issue. Obesity started from teenagers has become a major health
concern in recent years. Intermittent fasting increases the life span. However, it is not known …

The neuropathogenesis of postoperative delirium remains mostly unknown. The gut
microbiota is implicated in the pathogenesis of neurological disorders. We, therefore, set out …

Our previous study has reported that the proactive secretion and role of central high mobility
group box 1 (HMGB1) in lipopolysaccharide-induced depressive behavior. Here, the …

Delayed arousal and cognitive dysfunction are common, especially in older patients after
general anesthesia (GA). Elevating central nervous system serotonin (5-HT) levels can …

Sevoflurane is commonly used in clinical anesthesia. However, some reports indicated that
Sevoflurane could induce mitochondrial injury and neuroapoptosis. Although the …

Postoperative cognitive decline is a clinical syndrome. Volatile anesthetics are commonly
used during surgery. It is conceivable that volatile anesthetics may contribute to …