Mechanism of bile acid-induced programmed cell death and drug discovery against cancer: A review

JY Jang, E Im, YH Choi, ND Kim - International Journal of Molecular …, 2022 - mdpi.com
Bile acids are major signaling molecules that play a significant role as emulsifiers in the
digestion and absorption of dietary lipids. Bile acids are amphiphilic molecules produced by …

Roles and inhibitors of FAK in cancer: current advances and future directions

HH Hu, SQ Wang, HL Shang, HF Lv… - Frontiers in …, 2024 - frontiersin.org
Focal adhesion kinase (FAK) is a non-receptor tyrosine kinase that exhibits high expression
in various tumors and is associated with a poor prognosis. FAK activation promotes tumor …

The characteristics and the multiple functions of integrin β1 in human cancers

L Sun, S Guo, Y Xie, Y Yao - Journal of Translational Medicine, 2023 - Springer
Integrins, which consist of two non-covalently linked α and β subunits, play a crucial role in
cell–cell adhesion and cell-extracellular matrix (ECM) interactions. Among them, integrin β1 …

A predictive molecular signature consisting of lncRNAs associated with cellular senescence for the prognosis of lung adenocarcinoma

A Liu, X Wang, L Hu, D Yan, Y Yin, H Zheng, G Liu… - Plos one, 2023 - journals.plos.org
The role of long noncoding RNAs (lncRNAs) has been verified by more and more
researches in recent years. However, there are few reports on cellular senescence …

Combating anoikis resistance: bioactive compounds transforming prostate cancer therapy

S Gulia, P Chandra, A Das - Anti-Cancer Drugs, 2024 - journals.lww.com
The study aims to discuss the challenges associated with treating prostate cancer (PCa),
which is known for its complexity and drug resistance. It attempts to find differentially …

Revealing a Novel Methylated Integrin Alpha-8 Related to Extracellular Matrix and Anoikis Resistance Using Proteomic Analysis in the Immune Microenvironment of …

T Liu, W Ji, X Cheng, L Lv, X Yu, N Wang, M Li… - Molecular …, 2024 - Springer
Genomic epigenetics of extracellular matrix (ECM) play an important role in lung
adenocarcinoma (LUAD). Our study identified a signature of potential prognostic genes …

Development of a prognostic model for lung adenocarcinoma polarity‐related genes and analysis of immune landscape

H Xu, W Du, X Jing, J Xie, P Li - Biotechnology and Applied …, 2024 - Wiley Online Library
Despite the progress made in the management of lung adenocarcinoma (LUAD), the overall
prognosis for LUAD individuals remains suboptimal. While the role of cell polarity in tumor …

Mode of actions of bile acids in avoidance of colorectal cancer development; and their therapeutic applications in cancers-a narrative review

KK Kaur, GNK Allahbadia, M Singh - Journal of Pharmacy and …, 2022 - set-publisher.com
Abstract Bile Acids (BAs) possess a considerably significant part in the form of emulsifiers in
digestion besides absorption of dietary lipids. BAs represent amphiphilic molecules, that are …

Construction of a Prognostic Model for Lung Adenocarcinoma Based on Nucleotide Metabolism-Related Genes and Bioinformatics Analysis

X Cui, W Han, Y Li, R Zhang, G Zhu, H Huang, J Chen - 2024 - researchsquare.com
Background: Metabolic reprogramming is an important hallmark of cancer. However, it is still
uncertain how nucleotide metabolism-related genes (NMRGs) may affect the prognosis of …