The polycomb repressive complex 2 (PRC2) is a highly conserved histone H3 lysine 27
methyltransferase that regulates the expression of developmental genes. Inactivating …

Cbls are RING ubiquitin ligases that attenuate receptor tyrosine kinase (RTK) signal
transduction. Cbl ubiquitination activity is stimulated by phosphorylation of a linker helix …

Myeloid malignant diseases comprise chronic (including myelodysplastic syndromes,
myeloproliferative neoplasms and chronic myelomonocytic leukemia) and acute (acute …

3 Horton JK, Prasad R, Hou E, Wilson SH. Protection against methylation-induced
cytotoxicity by DNA polymerase b-dependent long patch base excision repair. J Biol Chem …

RAS-pathway mutations are recurrent events in myeloid malignancies. However, there is
limited data on the significance of RAS-pathway mutations in patients with myelofibrosis …

Background The origin and development of breast cancer remain complex and obscure.
Recently, microRNA (miRNA) has been identified as an important regulator of the initiation …

Myeloid neoplasms derive from the pathological clonal expansion of an abnormal stem cell
and span a diverse spectrum of phenotypes including acute myeloid leukaemia (AML) …

Progression of chronic myelogenous leukemia (CML) to accelerated (AP) and blast phase
(BP) is because of secondary molecular events, as well as additional cytogenetic …

Primary myelofibrosis (PMF) is one of three myeloproliferative neoplasms (MPN) that are
morphologically and molecularly inter-related, the other two being polycythemia vera (PV) …

In the 2008 WHO classification, chronic myeloid malignancies that share both
myelodysplastic and myeloproliferative features define the myelodysplastic …