Finding new analgesics: Computational pharmacology faces drug discovery challenges
Despite the worldwide prevalence and huge burden of pain, pain is an undertreated
phenomenon. Currently used analgesics have several limitations regarding their efficacy …
phenomenon. Currently used analgesics have several limitations regarding their efficacy …
Deep sequencing of Phox2a nuclei reveals five classes of anterolateral system neurons
AM Bell, C Utting, AC Dickie… - Proceedings of the …, 2024 - National Acad Sciences
The anterolateral system (ALS) is a major ascending pathway from the spinal cord that
projects to multiple brain areas and underlies the perception of pain, itch, and skin …
projects to multiple brain areas and underlies the perception of pain, itch, and skin …
[HTML][HTML] A systematic review and meta-analysis of anxiety-and depressive-like behaviors in rodent models of neuropathic pain
T de la Rosa, M Llorca-Torralba… - … Psychiatry Global Open …, 2024 - Elsevier
Background Epidemiological studies frequently reflect the concurrence of chronic pain with
symptoms of anxiety and depression, particularly in women. Animal models are useful to …
symptoms of anxiety and depression, particularly in women. Animal models are useful to …
Increased levels of advanced oxidation protein products (AOPPs) were associated with nociceptive behavior and clinical scores in an experimental progressive …
P Rodrigues, JM Frare, DS Peres… - Journal of …, 2024 - Wiley Online Library
Multiple sclerosis (MS) is a neurodegenerative disease that affects the central nervous
system (CNS) generating neuropathic pain and anxiety. Primary progressive MS (PPMS) is …
system (CNS) generating neuropathic pain and anxiety. Primary progressive MS (PPMS) is …
[HTML][HTML] Animal Models in Osteoarthritis Research: Pain Behavioral Methods and Clinical Significance
J Han, D Park, S Han - International Journal of Pain, 2023 - painresearch.or.kr
Osteoarthritis (OA) is a leading cause of chronic pain and disability worldwide. Animal
models are required to improve our understanding of the underlying pain mechanisms …
models are required to improve our understanding of the underlying pain mechanisms …