Molecular oxygen (O2) is a vital element in human survival and plays a major role in a
diverse range of biological and physiological processes. Although normobaric hyperoxia …

Stroke is deemed a worldwide leading cause of neurological disability and death, however,
there is currently no promising pharmacotherapy for acute ischemic stroke aside from …

Salvia miltiorrhiza (SM) has been used in oriental medicine for its neuroprotective effects
against cardiovascular diseases and ischemic stroke. In this study, we investigated the …

Hyperglycemia adversely affects the outcome of ischemic stroke. Extracellular HMGB1 plays
a role in aggravating brain damage in the postischemic brain. The aim of this study was to …

Stroke, one of the most debilitating cerebrovascular and nuerological diseases, is a serious
life-threatening condition and a leading cause of long-term adult disability and brain …

Nitrosative/oxidative stress plays an important role in neuronal death following cerebral
ischemia/reperfusion (I/R). Chrysophanol (CHR) has been shown to afford significant …

Background Even though more than 600 stroke treatments have been shown effective in
preclinical studies, clinically proven treatment alternatives for cerebral infarction remain …

Background Normobaric oxygen (NBO) has received considerable attention due to
controversial data in brain protection in patients with acute stroke. This study aims to analyze …

Nitric oxide (NO) was one of the key factors to sustain hypoxia-inducible factor-1-α (HIF-1α)
activation during hypoxia. However, the mechanism by which NO production promotes …

Preconditioning of the brain induces tolerance to the damaging effects of ischemia and
prevents cell death in ischemic penumbra. The development of this phenomenon is …