Degeneration of the intervertebral disc (IVD) is a normal part of aging. Due to the spine's
declining function and the development of pain, it may affect one's physical health, mental …

PIEZO1 and PIEZO2 are mechanosensitive cation channels that are highly expressed in
numerous tissues throughout the body and exhibit diverse, cell-specific functions in multiple …

Minimally invasive biodegradable implants with regeneration have been a frontier trend in
clinic. Degeneration of nucleus pulposus (NP) is irreversible in most of spine diseases, and …

Extracellular matrix (ECM) metabolism balance is essential for maintaining tissue structure
and function. However, the complex crosstalk between the ECM, resident cellular, and tissue …

Developing smart hydrogels with integrated and suitable properties to treat intervertebral
disc degeneration (IVDD) by minimally invasive injection is of high desire in clinical …

Low back pain (LBP) is a common problem worldwide, resulting in great patient suffering
and great challenges for the social health system. Intervertebral disc (IVD) degeneration …

Injectable hydrogels effectively remodel degenerative nucleus pulposus (NP) with a
resemblance to the in vivo microenvironment. However, the pressure within the …

As a global public health problem, low back pain (LBP) caused by intervertebral disc
degeneration (IDD) seriously affects patients' quality of life. In addition, the prevalence of …

Intervertebral disc degeneration (IDD) is a high incidence disease of musculoskeletal
system that often leads to stenosis, instability, pain and even deformity of the spinal …

Emerging evidence suggests that type 2 diabetes mellitus (T2DM) is associated with the
pathogenesis of intervertebral disc degeneration (IDD). However, it is still unclear how …