Role of the innate immune system in the pathogenesis of multiple sclerosis
Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease with heterogeneous
clinical presentations and course. MS is considered to be a T cell mediated disease but in …
clinical presentations and course. MS is considered to be a T cell mediated disease but in …
Innate and adaptive immune responses of the central nervous system
SL Bailey, PA Carpentier, EJ McMahon… - Critical Reviews™ in …, 2006 - dl.begellhouse.com
The central nervous system (CNS) is an immunologically specialized organ. The blood-brain
barrier regulates the passage of molecules and cells into the CNS. Robust immune …
barrier regulates the passage of molecules and cells into the CNS. Robust immune …
A novel probiotic mixture exerts a therapeutic effect on experimental autoimmune encephalomyelitis mediated by IL-10 producing regulatory T cells
S Lavasani, B Dzhambazov, M Nouri, F Fåk, S Buske… - PloS one, 2010 - journals.plos.org
Background Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease of the
central nervous system (CNS). One potential therapeutic strategy for MS is to induce …
central nervous system (CNS). One potential therapeutic strategy for MS is to induce …
Anti–IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis
Y Chen, CL Langrish, B Mckenzie… - The Journal of …, 2006 - Am Soc Clin Investig
IL-23 is a member of the IL-12 cytokine family that drives a highly pathogenic T cell
population involved in the initiation of autoimmune diseases. We have shown that IL-23 …
population involved in the initiation of autoimmune diseases. We have shown that IL-23 …
CNS myeloid DCs presenting endogenous myelin peptides 'preferentially' polarize CD4+ TH-17 cells in relapsing EAE
SL Bailey, B Schreiner, EJ McMahon, SD Miller - Nature immunology, 2007 - nature.com
Peripherally derived CD11b+ myeloid dendritic cells (mDCs), plasmacytoid DCs, CD8α+
DCs and macrophages accumulate in the central nervous system during relapsing …
DCs and macrophages accumulate in the central nervous system during relapsing …
IL-23 is increased in dendritic cells in multiple sclerosis and down-regulation of IL-23 by antisense oligos increases dendritic cell IL-10 production
A Vaknin-Dembinsky, K Balashov… - The Journal of …, 2006 - journals.aai.org
IL-23 is a heterodimeric cytokine comprising a p19 subunit associated with the IL-12/23p40
subunit. Like IL-12, IL-23 is expressed predominantly by activated dendritic cells (DCs) and …
subunit. Like IL-12, IL-23 is expressed predominantly by activated dendritic cells (DCs) and …
The immunomodulator glatiramer acetate augments the expression of neurotrophic factors in brains of experimental autoimmune encephalomyelitis mice
R Aharoni, R Eilam, H Domev… - Proceedings of the …, 2005 - National Acad Sciences
Neurotrophins (NTs) such as BDNF, NT-3, and NT-4 are important modulators of neuronal
function and survival. Their expression in the CNS after various insults is thus of major …
function and survival. Their expression in the CNS after various insults is thus of major …
[HTML][HTML] Characterization of the inflammatory cells in ascending thoracic aortic aneurysms in patients with Marfan syndrome, familial thoracic aortic aneurysms, and …
R He, DC Guo, W Sun, CL Papke, S Duraisamy… - The Journal of thoracic …, 2008 - Elsevier
OBJECTIVE: This study sought to characterize the inflammatory infiltrate in ascending
thoracic aortic aneurysm in patients with Marfan syndrome, familial thoracic aortic aneurysm …
thoracic aortic aneurysm in patients with Marfan syndrome, familial thoracic aortic aneurysm …
Minocycline down-regulates MHC II expression in microglia and macrophages through inhibition of IRF-1 and protein kinase C (PKC) α/βII
Experimental allergic encephalomyelitis, an autoimmune disorder mediated by T cells,
results in demyelination, inflammation, and axonal loss in the central nervous system (CNS) …
results in demyelination, inflammation, and axonal loss in the central nervous system (CNS) …
Proteinase-activated receptor 2 modulates neuroinflammation in experimental autoimmune encephalomyelitis and multiple sclerosis
The proteinase-activated receptors (PARs) are widely recognized for their modulatory
properties of inflammation and neurodegeneration. We investigated the role of PAR2 in the …
properties of inflammation and neurodegeneration. We investigated the role of PAR2 in the …