Mammalian erythropoiesis involves chromatin condensation that is initiated in the early
stage of terminal differentiation. The mechanisms of chromatin condensation during …

Organisms living under aerobic conditions need oxygen for the metabolic conversion of
nutrition into energy. With the appearance of increasingly complex animals, a specialized …

Abstract Background The Class I cytokine receptors have a wide range of actions, including
a major role in the development and function of immune and blood cells. However, the …

Background Regulated gene expression controls organismal development, and variation in
regulatory patterns has been implicated in complex traits. Thus accurate prediction of …

The recent discovery of an acquired activating point mutation in JAK2, substituting valine at
amino acid position 617 for phenylalanine, has greatly improved our understanding of the …

An increasing understanding of the process of erythropoiesis raises some interesting
questions about the pathophysiology, diagnosis and treatment of anemia and erythrocytosis …

Parkinson's disease (PD) is a chronic, neurodegenerative disease with a 1% incidence in
the population over 55 years of age. Movement impairments represent undoubtedly the …

GATA-1-dependent transcription is essential for erythroid differentiation and maturation.
Suppression of programmed cell death is also thought to be critical for this process; …

The role of erythropoietin (Epo) and Epo/Epo receptor (EpoR) signaling pathways for
production of red blood cells are well established. However, little is known about Epo/EpoR …

Background During the final stages of differentiation of mammalian erythroid cells, the
chromatin is condensed and enucleated. We previously reported that Rac GTPases and …