Recombinant human erythropoietin (rhEPO) has been used clinically to alleviate cancer-and
chemotherapy-related anemia. However, recent clinical trials have reported that rhEPO also …

The insulin receptor substrate (IRS) proteins are a family of cytoplasmic proteins that
integrate and coordinate the transmission of signals from the extracellular to the intracellular …

Previous observations suggested that functional antagonism between FLI-1 and EKLF might
be involved in the commitment toward erythrocytic or megakaryocytic differentiation. We …

Erythropoietin regulates erythropoiesis in a hypoxia-inducible manner. Here we generate
inherited super-anaemic mice (ISAM) as a mouse model of adult-onset anaemia caused by …

Erythropoiesis, the essential process of hematopoietic stem cell development into
erythrocytes, is controlled by lineage-specific transcription factors that determine cell fate …

Sox6 belongs to the Sry (sex-determining region Y)–related high-mobility-group–box family
of transcription factors, which control cell-fate specification of many cell types. Here, we …

Abstract Background Calcium (Ca2+) signaling regulates various vital cellular functions,
including integrin activation and cell migration. Store-operated calcium entry (SOCE) via …

Highlights•Erythropoietin (Epo) induces reactive oxygen species (ROS) production in early-
stage erythroblasts.•Oxidative status is correlated with CD71 expression and the uptake of …

Erythropoietin (EPO) signaling is critical to many processes essential to terminal
erythropoiesis. Despite the centrality of iron metabolism to erythropoiesis, the mechanisms …

Erythropoietin (Epo) is essential for the terminal proliferation and differentiation of erythroid
progenitor cells. Fibronectin is an important part of the erythroid niche, but its precise role in …