High-altitude polycythemia (HAPC) is one of the classic chronic mountain sicknesses and
has been a serious public health problem in high-altitude regions. Despite numerous …

EPO functions primarily as an erythroblast survival factor, and its antiapoptotic actions have
been proposed to involve predominantly PI3-kinase and BCL-X pathways. Presently, the …

Red blood cell production (erythropoiesis) is the single largest consumer of iron in the body;
this need is satisfied by maintaining a sensitive regulation of iron levels. The level of …

Enucleation, the final step in terminal differentiation of mammalian red blood cells, is an
essential process in which the nucleus surrounded by the plasma membrane is budded off …

Erythropoietin (EPO's) actions on erythroblasts are ascribed largely to survival effects.
Certain studies, however, point to EPO-regulated proliferation. To investigate this problem in …

Objectives Anemia is a known driver for hypoxia inducible factor (HIF) which leads to
increased renal erythropoietin (EPO) synthesis. Bone marrow (BM) EPO receptor (EPOR) …

Some time ago, we proposed a continuum-like view of the lineages open to hematopoietic
stem cells (HSCs); each HSC self-renews or chooses from the spectrum of all end-cell …

To improve clinical outcomes in patients presenting with an acute myocardial infarction, new
strategies to limit infarct size and postinfarct remodelling are warranted. Recent animal …

The distinct molecular structure of darbepoetin alfa, in both its amino acid sequence and its
carbohydrate content, results in a biologic profile with lower binding affinity, longer …

Transient receptor potential canonical (TRPC) channels are Ca 2+-permeable, nonselective
cation channels formed by homomeric or heteromeric complexes of TRPC proteins that …