Despite decades of suppressive antiretroviral therapy, human immunodeficiency virus (HIV)
reservoirs in infected individuals persist and fuel viral rebound once therapy is interrupted …

Acquired immunodeficiency syndrome (AIDS), a serious public health concern worldwide, is
predominantly caused by human immunodeficiency virus type 1 (HIV-1). More than 30 drugs …

Macrophages can serve as a reservoir for human immunodeficiency-1 (HIV-1) virus in host
cells, constituting a barrier to eradication, even in patients who are receiving antiretroviral …

In the early 2000s, novel humanized mouse models based on the transplantation of human
hematopoietic stem and progenitor cells (HSPCs) into immunocompromised mice were …

Despite remarkable progress, a cure for HIV-1 infection remains elusive. Rebound
competent latent and transcriptionally active reservoir cells persevere despite antiretroviral …

The aryl hydrocarbon receptor (AhR) regulates Th17-polarized CD4+ T cell functions, but its
role in HIV-1 replication/outgrowth remains unknown. Genetic (CRISPR-Cas9) and …

Despite its high effectiveness, combination antiretroviral treatment (cART) has a limited
effect on HIV-DNA reservoir, which establishes early during primary infection (PHI) and is …

Worldwide, almost 40 million people are currently living with HIV-1. The implementation of
cART inhibits HIV-1 replication and reduces viremia but fails to eliminate HIV-1 from latently …

HIV latent infection may be associated with disrupted viral RNA sensing, interferon (IFN)
signaling, and/or IFN stimulating genes (ISG) activation. Here, we evaluated the use of …

SUMMARY The Aryl hydrocarbon receptor (AhR) regulates Th17-polarized CD4+ T-cell
functions, but its role in HIV-1 replication/outgrowth remains unknown. Genetic …