Skin pigmentation is due to the accumulation of two types of melanin granules in the
keratinocytes. Besides being the most potent blocker of ultraviolet radiation, the role of …

Visible pigmentation of the skin, hair, and eyes depends primarily on the presence of
melanin (s) in those tissues. Melanins are produced by specific cells called melanocytes …

Some amino acids have bioregulatory functions, which far exceed those of precursors for
proteins or of substrates for specific enzymes. Two of these amino acids, L-tyrosine and L …

The size of the melanocyte system in humans was estimated as though all active
melanocytes in the body were assembled in a single compact organ. Our estimates indicate …

L-DOPA, the product of enzymatic hydroxylation of L-tyrosine, is released by melanotic
melanoma cells in vivo and in vitro. Here we report that DOPA at pharmacologically relevant …

1 Murine melanoma melanosomal tyrosinase, solubilised at pH 6.8 and 1% Igepal, exhibits
a lag in cresolase activity which increases with increasing concentration of tyrosine. 2 The …

Abstract Models of animal melanoma are still indispensable tools in oncological research
because they can be studied in syngeneic hosts while human melanomas cannot. One such …

Rapid, saturable, specific and stereoselective binding of L-dopa to crude membranes and
membranes and purified nuclei from rodent amelanotic melanoma cells is reported. Cross …

The distribution of γ-glutamyl transpeptidase (γ-GTP), tyrosinase, and 5-S-cysteinyldopa (5-
S-CD) within melanoma cells has been studied in vitro as well as in vivo. Sodium periodate …

L‐DOPA had no effect on the endogenous phosphorylation of proteins after extraction with
1% Triton X‐100 from hamster melanoma. When proteins were purified further by wheat …