Cardiac injury, such as myocardial infarction and heart failure, remains a significant global
health burden. The limited regenerative capacity of the adult heart poses a challenge for …

Despite improvements in clinical outcomes following acute myocardial infarction, mortality
remains high, especially in patients with severely reduced left ventricular ejection fraction …

Critical challenges remain in clinical translation of extracellular vesicle (EV)-based
therapeutics due to the absence of methods to enrich cells with high EV secretion. Current …

Cardiovascular diseases (CVDs) stand as the leading cause of death worldwide, posing a
significant global health challenge. Consequently, the development of innovative …

Myocardial infarction, usually caused by the rupture of atherosclerotic plaque, leads to
irreversible ischemic cardiomyocyte death within hours followed by impaired cardiac …

Ischemic heart diseases remain the leading cause of death globally, and stem cell-based
therapy has been investigated as a potential approach for cardiac repair. Due to poor …

Chemotherapy-induced cardiotoxicity with subsequent heart failure (HF) is a major cause of
morbidity and mortality in cancer survivors worldwide. Chemotherapy-induced HF is …

The embryonic epicardium originates from the proepicardium, an extracardiac primordium
constituted by a cluster of mesothelial cells. In early embryos, the embryonic epicardium is …

Effective intercellular communication is essential for cellular and tissue balance
maintenance and response to challenges. Cellular communication methods involve direct …

Myocardial infarction (MI) is one of the most prevalent types of cardiovascular disease.
During MI, myocardial cells become ischemic and necrotic due to inadequate blood …