Apparent changes in the epidemiology and severity of multiple sclerosis

N Koch-Henriksen, M Magyari - Nature Reviews Neurology, 2021 - nature.com
Multiple sclerosis (MS) is an immunological disease that causes acute inflammatory lesions
and chronic inflammation in the CNS, leading to tissue damage and disability. As awareness …

[HTML][HTML] Incidence and prevalence of multiple sclerosis in Europe: a systematic review

E Kingwell, JJ Marriott, N Jetté, T Pringsheim… - BMC neurology, 2013 - Springer
Background Multiple sclerosis (MS) is the most common cause of neurological disability in
young adults worldwide and approximately half of those affected are in Europe. The …

Epidemiology of multiple sclerosis

E Leray, T Moreau, A Fromont, G Edan - Revue neurologique, 2016 - Elsevier
Multiple sclerosis (MS) is the most frequently seen demyelinating disease, with a prevalence
that varies considerably, from high levels in North America and Europe (> 100/100,000 …

The changing demographic pattern of multiple sclerosis epidemiology

N Koch-Henriksen, PS Sørensen - The Lancet Neurology, 2010 - thelancet.com
The uneven distribution of multiple sclerosis (MS) across populations can be attributed to
differences in genes and the environment and their interaction. Prevalence and incidence …

Recent insights in the epidemiology of autoimmune diseases: improved prevalence estimates and understanding of clustering of diseases

GS Cooper, MLK Bynum, EC Somers - Journal of autoimmunity, 2009 - Elsevier
Previous studies have estimated a prevalence of a broad grouping of autoimmune diseases
of 3.2%, based on literature review of studies published between 1965 and 1995, and 5.3 …

[HTML][HTML] Multiple sclerosis incidence: A systematic review of change over time by geographical region

J Lane, HS Ng, C Poyser, RM Lucas… - Multiple Sclerosis and …, 2022 - Elsevier
Background The incidence of multiple sclerosis (MS) has reportedly increased over time;
however, change in MS incidence has not been rigorously assessed globally. Methods We …

[HTML][HTML] Geographical variations in sex ratio trends over time in multiple sclerosis

M Trojano, G Lucchese, G Graziano, BV Taylor… - PloS one, 2012 - journals.plos.org
Background A female/male (F/M) ratio increase over time in multiple sclerosis (MS) patients
was demonstrated in many countries around the world. So far, a direct comparison of sex …

Peroxisome proliferator-activated receptor (PPAR) α and-γ regulate IFNγ and IL-17A production by human T cells in a sex-specific way

MA Zhang, D Rego, M Moshkova… - Proceedings of the …, 2012 - National Acad Sciences
Women develop certain autoimmune diseases more often than men. It has been
hypothesized that this may relate to the development of more robust T-helper (Th) 1 …

Epidemiology of multiple sclerosis

SV Ramagopalan, AD Sadovnick - Neurologic clinics, 2011 - neurologic.theclinics.com
Multiple sclerosis (MS) is the most common disease of the central nervous system that
causes permanent disability in young adults. 1 Based on strong circumstantial evidence, MS …

Higher levels of 25-hydroxyvitamin D are associated with a lower incidence of multiple sclerosis only in women

JJ Kragt, BM Van Amerongen… - Multiple Sclerosis …, 2009 - journals.sagepub.com
Introduction Multiple sclerosis (MS) is a chronic inflammatory disease with an as yet not fully
understood etiological background. The geographical distribution of MS is striking with a …