Why do patients with cancer die?

A Boire, K Burke, TR Cox, T Guise… - Nature Reviews …, 2024 - nature.com
Cancer is a major cause of global mortality, both in affluent countries and increasingly in
developing nations. Many patients with cancer experience reduced life expectancy and …

Nutritional Mechanisms of Cancer Cachexia

SLE Compton, SB Heymsfield… - Annual Review of …, 2024 - annualreviews.org
Cancer cachexia is a complex systemic wasting syndrome. Nutritional mechanisms that
span energy intake, nutrient metabolism, body composition, and energy balance may be …

Ponsegromab for the Treatment of Cancer Cachexia

JD Groarke, J Crawford, SM Collins… - … England Journal of …, 2024 - Mass Medical Soc
Background Cachexia is a common complication of cancer and is associated with an
increased risk of death. The level of growth differentiation factor 15 (GDF-15), a circulating …

Development of a peptide drug restoring AMPK and adipose tissue functionality in cancer cachexia

H Ji, F Englmaier, P Morigny, M Giroud, P Gräsle… - Molecular Therapy, 2023 - cell.com
Cancer cachexia is a severe systemic wasting disease that negatively affects quality of life
and survival in patients with cancer. To date, treating cancer cachexia is still a major unmet …

Cancer cachexia: biomarkers and the influence of age

J Geppert, M Rohm - Molecular Oncology, 2024 - Wiley Online Library
Cancer cachexia (Ccx) is a complex metabolic condition characterized by pronounced
muscle and fat wasting, systemic inflammation, weakness and fatigue. Up to 30% of cancer …

[HTML][HTML] Malnutrition in cancer patients: causes, consequences and treatment options

J Arends - European Journal of Surgical Oncology, 2024 - Elsevier
Cancer patients are at a high risk of malnutrition and disease-associated catabolic
derangements. It is important to differentiate between 'simple'–voluntary or involuntary …

Addressing cancer anorexia-cachexia in older patients: potential therapeutic strategies and molecular pathways

T Ispoglou, D McCullough, A Windle, S Nair, N Cox… - Clinical Nutrition, 2024 - Elsevier
Cancer cachexia (CC) syndrome, a feature of cancer-associated muscle wasting, is
particularly pronounced in older patients, and is characterised by decreased energy intake …

Tumoral acidosis promotes adipose tissue depletion by fostering adipocyte lipolysis

C Lefevre, MM Thibaut, A Loumaye, JP Thissen… - Molecular …, 2024 - Elsevier
Objective Tumour progression drives profound alterations in host metabolism, such as
adipose tissue depletion, an early event of cancer cachexia. As fatty acid consumption by …

Simultaneous Learning of Erector Spinae Muscles for Automatic Segmentation of Site-Specific Skeletal Muscles in Body CT Images

M Kawamoto, N Kamiya, X Zhou, H Kato, T Hara… - IEEE …, 2023 - ieeexplore.ieee.org
Skeletal muscle segmentation of the L3 slice can be used to estimate total body skeletal
muscle mass. However, site-specific three-dimensional (3D) segmentation of each region …

[HTML][HTML] Thoracic CT imaging in obesity: Technical Challenges, imaging findings and future outlook

P Suwathep, A Sheeka, S Copley - Meta-Radiology, 2024 - Elsevier
Obesity is a highly prevalent and increasing global medical problem. It is expected that most
radiologists will come across computed tomography studies of obese patients in their daily …