Efficacy of concurrent chemoradiotherapy with S-1 vs radiotherapy alone for older patients with esophageal cancer: a multicenter randomized phase 3 clinical trial

Y Ji, X Du, W Zhu, Y Yang, J Ma, L Zhang, J Li… - JAMA …, 2021 - jamanetwork.com
Importance Most older patients with esophageal cancer cannot complete the standard
concurrent chemoradiotherapy (CCRT). An effective and tolerable chemoradiotherapy …

Treatment and clinical outcome of clinical T4 esophageal cancer: a systematic review

T Makino, M Yamasaki, K Tanaka… - Annals of …, 2019 - Wiley Online Library
Background Survival of patients with cT 4 esophageal cancer is dismal. Although the optimal
treatment strategy remains to be established, two treatment options are available for cT 4 …

Geriatric Radiation Oncology: What We Know and What Can We Do Better?

F Roeder, AD Jensen, K Lindel, M Mattke… - … Interventions in Aging, 2023 - Taylor & Francis
Elderly patients represent a growing subgroup of cancer patients for whom the role of
radiation therapy is poorly defined. Older patients are still clearly underrepresented in …

[HTML][HTML] Cirsiliol targets tyrosine kinase 2 to inhibit esophageal squamous cell carcinoma growth in vitro and in vivo

X Jia, C Huang, Y Hu, Q Wu, F Liu, W Nie… - Journal of Experimental …, 2021 - Springer
Background Esophageal squamous cell carcinoma (ESCC) is an aggressive and lethal
cancer with a low 5 year survival rate. Identification of new therapeutic targets and its …

[HTML][HTML] Individualized treatment decision model for inoperable elderly esophageal squamous cell carcinoma based on multi-modal data fusion

Y Huang, X Huang, A Wang, Q Chen, G Chen… - BMC Medical Informatics …, 2023 - Springer
Background This research aimed to develop a model for individualized treatment decision-
making in inoperable elderly patients with esophageal squamous cell carcinoma (ESCC) …

Survival impact of concurrent chemoradiotherapy for elderly patients with synchronous oligometastatic esophageal squamous cell carcinoma: A propensity score …

Z Shi, X Zhu, S Ke, H Qiu, G Cai, Y Zhangcai… - Radiotherapy and …, 2021 - Elsevier
Purpose To evaluate the potential benefits of concurrent chemoradiotherapy (CCRT), and to
establish a nomogram for predicting survival outcomes of elderly patients with synchronous …

The role of radiation therapy in the older patient

A Dohm, R Diaz, RH Nanda - Current Oncology Reports, 2021 - Springer
Abstract Purpose of Review Older patients represent a unique subgroup of the cancer
patient population for which the role of radiation therapy (RT) requires special consideration …

Prognostic impact of muscle mass loss in elderly patients with oesophageal cancer receiving neoadjuvant chemoradiation therapy

JY Jang, D Oh, JM Noh, JM Sun… - Journal of Cachexia …, 2024 - Wiley Online Library
Background We aimed to identify the impact of muscle mass on locally advanced
oesophageal cancer (LAEC) in elderly patients receiving neoadjuvant chemoradiation …

Safety of radiotherapy with concurrent docetaxel in older patients with esophageal cancer

T Kawamoto, N Shikama, M Oshima, Y Kosugi… - Journal of Geriatric …, 2020 - Elsevier
Objectives Considering that therapeutic strategies for older adult patients with esophageal
cancer (EC) remain controversial, we aimed to assess the safety of radiotherapy with …

[HTML][HTML] Radiotherapy with S-1 for the treatment of esophageal squamous cell carcinoma 75 years or older

D Gu, T Wang, Y Guo, Y Liu, Y Fang, W Chen… - Radiation …, 2024 - Springer
Objective Explore the efficacy and safety of involved-field irradiation (IFI) combined with S-1
as definitive concurrent chemoradiotherapy (dCRT) for locally advanced elderly esophageal …