Abstract Purpose In 2005 the International Committee of Medical Journal Editors issued a
requirement that all randomized controlled trials (RCTs) be registered primarily to prevent …

Objective Informed consent (IC) is a central ethical and legal requirement for clinical
research that aims to protect the autonomy of participants. To enable an autonomous …

Objective: To assess the degree of agreement between propensity score studies and
randomized clinical trials in critical care research. Data Sources: Propensity score studies …

Background In the course of the COVID-19 pandemic, the biomedical research community's
attempt to focus the attention on fighting COVID-19, led to several challenges within the field …

Repeatedly, adequacy, performance and quality of Ethics Committees that oversee medical
research trials are being discussed. Although they play a crucial role in reviewing medical …

Background: Numerous studies of community reintegration (CR) in traumatic brain injury
(TBI) have been conducted in civilian populations, but research is limited in veteran and …

Background Clinical trials in critical care are often resource-intense, with many unique
challenges. Barriers to effective recruitment and implementation of study intervention have …

A vulnerable participant in research lacks capacity to consent or may be exposed to
coercion to participate. Capacity may be temporarily impaired due to loss of consciousness …

Obtaining written informed consent from participants before enrolment in a study is essential.
A previous study showed that only 50% of the participants in clinical trials understood the …

Historically, pregnant women have generally been excluded from clinical trials. One of the
reasons for this exclusion has been the belief that pregnant women are vulnerable as …