Abstract Purpose of Review The opioid epidemic has been responsible for significant
morbidity and mortality in the USA and worldwide. As a result, it is essential to recognize the …

Introduction: The recreational use of fentanyl in combination with xylazine (ie,“tranq-dope”)
represents a rapidly emerging public health threat characterized by significant toxicity and …

Background Overdose deaths involving stimulants and opioids simultaneously have raised
the specter of widespread contamination of the stimulant supply with fentanyl. Methods We …

Xylazine abuse is emerging globally, while the identification of xylazine lethal cases poses a
great challenge in clinical and forensic practice. The non-specific symptoms delay the …

In the 1960s, Bayer 1470, an alpha2-adrenergic agonist similar to clonidine, was
investigated as an antihypertensive in humans, only to be abandoned because it produced …

Background Death certificate data provide powerful and sobering records of the opioid
overdose crisis. In Massachusetts, where address-level decedent data are publicly available …

Introduction In the US, xylazine, the veterinary non-opioid sedative, has emerged as a major
threat to people who use illicitly manufactured fentanyl and other drugs. The aim of this study …

Background Location and environmental social determinants of health are increasingly
important factors in both an individual's health and the monitoring of community-level public …

Xylazine, or “tranq,” is a veterinary anesthetic recognized as a highly potent and potentially
lethal adulterant in community supplies of opioids, benzodiazepines, and cocaine. 1 Here …