Cell-based and stem-cell-based treatments for spinal cord injury: evidence from clinical trials
Spinal cord injury is a severely disabling neurological condition leading to impaired mobility,
pain, and autonomic dysfunction. Most often, a single traumatic event, such as a traffic or …
pain, and autonomic dysfunction. Most often, a single traumatic event, such as a traffic or …
[HTML][HTML] Spinal cord injury: molecular mechanisms and therapeutic interventions
X Hu, W Xu, Y Ren, Z Wang, X He, R Huang… - … and Targeted Therapy, 2023 - nature.com
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …
The challenges of SCI repair include its complex pathological mechanisms and the …
[HTML][HTML] A reactive oxygen species-responsive hydrogel encapsulated with bone marrow derived stem cells promotes repair and regeneration of spinal cord injury
Z Li, T Zhao, J Ding, H Gu, Q Wang, Y Wang, D Zhang… - Bioactive Materials, 2023 - Elsevier
Spinal cord injury (SCI) is an overwhelming and incurable disabling event accompanied by
complicated inflammation-related pathological processes, such as excessive reactive …
complicated inflammation-related pathological processes, such as excessive reactive …
Emergency treatment and photoacoustic assessment of spinal cord injury using reversible dual‐signal transform‐based selenium antioxidant
Spinal cord injury (SCI), following explosive oxidative stress, causes an abrupt and
irreversible pathological deterioration of the central nervous system. Thus, preventing …
irreversible pathological deterioration of the central nervous system. Thus, preventing …
Advances in biomaterial‐based spinal cord injury repair
H Shen, C Fan, Z You, Z Xiao… - Advanced Functional …, 2022 - Wiley Online Library
Spinal cord injury (SCI) often leads to the loss of motor and sensory functions and is a major
challenge in neurological clinical practice. Understanding the pathophysiological changes …
challenge in neurological clinical practice. Understanding the pathophysiological changes …
Carrier-free nanodrug based on co-assembly of methylprednisolone dimer and Rutin for combined treatment of spinal cord injury
H Wang, F Lin, Y Wu, W Guo, X Chen, C Xiao… - ACS nano, 2023 - ACS Publications
Spinal cord injury (SCI), which is characterized by excessive inflammatory cell infiltration
and accumulation of oxidative substance, would severely impede neurological functional …
and accumulation of oxidative substance, would severely impede neurological functional …
[HTML][HTML] Management of acute traumatic spinal cord injury: a review of the literature
Traumatic spinal cord injury (TSCI) is a debilitating disease that poses significant functional
and economic burden on both the individual and societal levels. Prognosis is dependent on …
and economic burden on both the individual and societal levels. Prognosis is dependent on …
Nerve growth factor-laden anisotropic silk nanofiber hydrogels to regulate neuronal/astroglial differentiation for scarless spinal cord repair
X Gao, W Cheng, X Zhang, Z Zhou, Z Ding… - … Applied Materials & …, 2022 - ACS Publications
Scarless spinal cord regeneration remains a challenge due to the complicated
microenvironment at lesion sites. In this study, the nerve growth factor (NGF) was …
microenvironment at lesion sites. In this study, the nerve growth factor (NGF) was …
Effect of early vs delayed surgical treatment on motor recovery in incomplete cervical spinal cord injury with preexisting cervical stenosis: a randomized clinical trial
H Chikuda, Y Koyama, Y Matsubayashi… - JAMA network …, 2021 - jamanetwork.com
Importance The optimal management for acute traumatic cervical spinal cord injury (SCI) is
unknown. Objective To determine whether early surgical decompression results in better …
unknown. Objective To determine whether early surgical decompression results in better …
Is graphene shortening the path toward spinal cord regeneration?
Along with the development of the next generation of biomedical platforms, the inclusion of
graphene-based materials (GBMs) into therapeutics for spinal cord injury (SCI) has potential …
graphene-based materials (GBMs) into therapeutics for spinal cord injury (SCI) has potential …