Cell-based and stem-cell-based treatments for spinal cord injury: evidence from clinical trials

CM Zipser, JJ Cragg, JD Guest, MG Fehlings… - The Lancet …, 2022 - thelancet.com
Spinal cord injury is a severely disabling neurological condition leading to impaired mobility,
pain, and autonomic dysfunction. Most often, a single traumatic event, such as a traffic or …

[HTML][HTML] Spinal cord injury: molecular mechanisms and therapeutic interventions

X Hu, W Xu, Y Ren, Z Wang, X He, R Huang… - … and Targeted Therapy, 2023 - nature.com
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …

[HTML][HTML] A reactive oxygen species-responsive hydrogel encapsulated with bone marrow derived stem cells promotes repair and regeneration of spinal cord injury

Z Li, T Zhao, J Ding, H Gu, Q Wang, Y Wang, D Zhang… - Bioactive Materials, 2023 - Elsevier
Spinal cord injury (SCI) is an overwhelming and incurable disabling event accompanied by
complicated inflammation-related pathological processes, such as excessive reactive …

Emergency treatment and photoacoustic assessment of spinal cord injury using reversible dual‐signal transform‐based selenium antioxidant

Z Ji, J Zheng, Y Ma, H Lei, W Lin, J Huang, H Yang… - Small, 2023 - Wiley Online Library
Spinal cord injury (SCI), following explosive oxidative stress, causes an abrupt and
irreversible pathological deterioration of the central nervous system. Thus, preventing …

Advances in biomaterial‐based spinal cord injury repair

H Shen, C Fan, Z You, Z Xiao… - Advanced Functional …, 2022 - Wiley Online Library
Spinal cord injury (SCI) often leads to the loss of motor and sensory functions and is a major
challenge in neurological clinical practice. Understanding the pathophysiological changes …

Carrier-free nanodrug based on co-assembly of methylprednisolone dimer and Rutin for combined treatment of spinal cord injury

H Wang, F Lin, Y Wu, W Guo, X Chen, C Xiao… - ACS nano, 2023 - ACS Publications
Spinal cord injury (SCI), which is characterized by excessive inflammatory cell infiltration
and accumulation of oxidative substance, would severely impede neurological functional …

[HTML][HTML] Management of acute traumatic spinal cord injury: a review of the literature

TY Wang, C Park, H Zhang, S Rahimpour… - Frontiers in …, 2021 - frontiersin.org
Traumatic spinal cord injury (TSCI) is a debilitating disease that poses significant functional
and economic burden on both the individual and societal levels. Prognosis is dependent on …

Nerve growth factor-laden anisotropic silk nanofiber hydrogels to regulate neuronal/astroglial differentiation for scarless spinal cord repair

X Gao, W Cheng, X Zhang, Z Zhou, Z Ding… - … Applied Materials & …, 2022 - ACS Publications
Scarless spinal cord regeneration remains a challenge due to the complicated
microenvironment at lesion sites. In this study, the nerve growth factor (NGF) was …

Effect of early vs delayed surgical treatment on motor recovery in incomplete cervical spinal cord injury with preexisting cervical stenosis: a randomized clinical trial

H Chikuda, Y Koyama, Y Matsubayashi… - JAMA network …, 2021 - jamanetwork.com
Importance The optimal management for acute traumatic cervical spinal cord injury (SCI) is
unknown. Objective To determine whether early surgical decompression results in better …

Is graphene shortening the path toward spinal cord regeneration?

AF Girão, MC Serrano, A Completo, PAAP Marques - ACS nano, 2022 - ACS Publications
Along with the development of the next generation of biomedical platforms, the inclusion of
graphene-based materials (GBMs) into therapeutics for spinal cord injury (SCI) has potential …