Cholesterol is essential for cell function and viability. It is a component of the plasma
membrane and lipid rafts and is a precursor for bile acids, steroid hormones, and Vitamin D …

The accumulation of cholesterol is a general feature of cancer tissue, and recent evidence
suggests that cholesterol plays critical roles in the progression of cancers, including breast …

Human brain organoids generated with current technologies recapitulate histological
features of the human brain, but they lack a reproducible topographic organization. During …

ADAM metalloproteinase disintegrins have emerged as the major proteinase family that
mediates ectodomain shedding, the proteolytic release of extracellular domains from their …

Lipid rafts and caveolae play a pivotal role in organization of signaling by TLR4 and several
other immune receptors. Beyond the simple cataloguing of signaling events …

Ectodomain shedding is a proteolytic mechanism by which transmembrane molecules are
converted into a soluble form. Cleavage is mediated by metalloproteases and proceeds in a …

The extracellular domain of several membrane‐anchored proteins is released from the cell
surface as soluble proteins through a regulated proteolytic mechanism called ectodomain …

ALL AUTHORS: Phillip CC Liu, Xiangdong Liu, Yanlong Li, Maryanne Covington, Richard
Wynn, Reid Huber, Milton Hillman, Gengjie Yang, Dawn Ellis, Cindy Marando, Kamna …

The recent emergence of coronavirus disease-2019 (COVID-19) as a global pandemic has
prompted scientists to address an urgent need for defining mechanisms of disease …

CD44 is a cell surface adhesion molecule for hyaluronan and is implicated in tumor invasion
and metastasis. Proteolytic cleavage of CD44 plays a critical role in the migration of tumor …