Importance Mortality among people with opioid dependence is higher than that of the
general population. Opioid agonist treatment (OAT) is an effective treatment for opioid …

Opioids are widely used as therapeutic agents against moderate to severe acute and
chronic pain. Still, these classes of analgesic drugs have many potential limitations as they …

The purpose of this comprehensive review is to describe various aspects of crisis of opioid
use in the United States. The obstacles that must be surmounted are primarily inappropriate …

This paper reviews studies examining the pharmacological interactions and epidemiology of
the combined use of opioids and benzodiazepines (BZDs). A search of English language …

Patients with neuropathic pain (NP) are challenging to manage and evidence-based clinical
recommendations for pharmacologic management are needed. Systematic literature …

Opioids have been regarded for millennia as among the most effective drugs for the
treatment of pain. Their use in the management of acute severe pain and chronic pain …

Increasing concern about the risks and limited evidence supporting the therapeutic benefit of
long-term opioid therapy for chronic noncancer pain are leading prescribers to consider …

Objective To report trends and characteristics of long‐term opioid use for non‐cancer pain.
Methods CONSORT (CONsortium to Study Opioid Risks and Trends) includes adult …

Pain and pleasure are powerful motivators of behaviour and have historically been
considered opposites. Emerging evidence from the pain and reward research fields points to …

New studies of the treatment of neuropathic pain have increased the need for an updated
review of randomized, double-blind, placebo-controlled trials to support an evidence based …