Memory and motor deficits are commonly identified in Parkinson's disease (PD). 1-Methyl-4-
phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) is transformed to MPP+ via monoamine oxidase …

The human motor cortex comprises a microcircuit of five interconnected layers with different
cell types. In this Review, we use a layer-specific and cell-specific approach to integrate …

The primary motor cortex (M1) is crucial for movement execution, especially dexterous ones,
but also for cognitive functions like motor learning. The acquisition of motor skills to execute …

Drug exposure impairs cortical plasticity and motor learning, which underlies the reduced
behavioral flexibility in drug addiction. Physical exercise has been used to prevent relapse …

Despite the obvious differences in the pathophysiology of distinct neuropsychiatric diseases
or neurodegenerative disorders, some of them share some general but pivotal mechanisms …

The aggregation of TAR DNA binding protein 43 kDa (TDP-43) is related to different
neurodegenerative diseases, which leads to microglial activation and neuronal loss. The …

Chemogenetics enables precise, non-invasive, and reversible modulation of neural activity
via the activation of engineered receptors that are pharmacologically selective to …

Electroacupuncture (EA) has been accepted to effectively relieve neuropathic pain. Current
knowledge of its neural modulation mainly covers the spinal cord and subcortical nuclei …

Chronic stress is a major risk factor for developing mental illnesses and cognitive
deficiencies although stress-susceptibility varies individually. In a recent study, we …

A few developmental genes remain persistently expressed in the adult stage, whilst their
potential functions in the mature brain remain underappreciated. Here, we report the …