Recent studies demonstrated that pyroptosis plays a crucial role in shaping the tumor-
immune microenvironment. However, the influence of pyroptosis on lower-grade glioma …

Purpose Astrocytomas and oligodendrogliomas are mainly diffuse primary brain tumors
harboring a diagnostic and prognostically favorable isocitrate dehydrogenase mutation …

Background Despite the putatively targetable genomic landscape of high-grade gliomas, the
long-term survival benefit of genomically-tailored targeted therapies remains discouraging …

Glioblastoma (GBM) is a highly malignant brain tumor with a dismal prognosis. Standard
therapy for GBM comprises surgical resection, followed by radiotherapy plus concomitant …

Background and purpose Diffuse midline glioma H3K27-altered (DMG) is an aggressive,
inoperable, predominantly paediatric brain tumour. Treatment strategies are limited …

PARP was an enzyme found in the nucleus of eukaryotic cells that played a crucial role in
repairing damaged DNA. Recently, PARP inhibitors have demonstrated great potential in …

Glioblastoma (GBM) is a highly invasive primary brain tumor in adults with a 5-year survival
rate of less than 10%. Conventional radiotherapy with photons, along with concurrent and …

The chemokine CXCL12 promotes glioblastoma (GBM) recurrence after radiotherapy (RT)
by facilitating vasculogenesis. Here we report outcomes of the dose-escalation part of …

Glioblastoma (GBM) is an intrinsically treatment-resistant tumor and has been shown to
upregulate DNA damage response (DDR) components after treatment. DNA damage …

Background Glioblastoma (GBM) is the most frequent type of primary brain cancer, having a
median survival of only 15 months. The current standard of care includes a combination of …