Differences and similarities between cancer and somatic stem cells: therapeutic implications

F Rossi, H Noren, R Jove, V Beljanski… - Stem cell research & …, 2020 - Springer
Over the last decades, the cancer survival rate has increased due to personalized therapies,
the discovery of targeted therapeutics and novel biological agents, and the application of …

MicroRNAs, regulatory messengers inside and outside cancer cells

S Anfossi, X Fu, R Nagvekar, GA Calin - Exosomes, Stem Cells and …, 2018 - Springer
MicroRNAs (miRNAs) are a class of short non-coding RNAs (ncRNAs) with typical sequence
lengths of 19–25 nucleotides and extraordinary abilities to regulate gene expression …

MicroRNAs and their delivery in diabetic fibrosis

A Wonnacott, L Denby, RJM Coward, DJ Fraser… - Advanced drug delivery …, 2022 - Elsevier
The global prevalence of diabetes mellitus was estimated to be 463 million people in 2019
and is predicted to rise to 700 million by 2045. The associated financial and societal costs of …

The story of EGFR: from signaling pathways to a potent anticancer target

S Ramani, S Samant, SM Manohar - Future Medicinal Chemistry, 2022 - Taylor & Francis
EGFR is a member of the ERBB family. It plays a significant role in cellular processes such
as growth, survival and differentiation via the activation of various signaling pathways. EGFR …

Non-coding RNAs: the cancer genome dark matter that matters!

H Ling, L Girnita, O Buda, GA Calin - Clinical Chemistry and …, 2017 - degruyter.com
Protein-coding genes comprise only 3% of the human genome, while the genes that are
transcribed into RNAs but do not code for proteins occupy majority of the genome. Once …

Novel anti-inflammatory target of geniposide: inhibiting Itgβ1/Ras-Erk1/2 signal pathway via the miRNA-124a in rheumatoid arthritis synovial fibroblasts

Y Wang, L Dai, H Wu, Z Zhang, W Wang, J Fu… - International …, 2018 - Elsevier
Geniposide (GE) is an active component isolated from the fruit of Gardenia jasminoides Ellis
that has anti-inflammatory and other pharmacological effects; however, the underlying …

Regulators at Every Step—How microRNAs Drive Tumor Cell Invasiveness and Metastasis

TM Grzywa, K Klicka, PK Włodarski - Cancers, 2020 - mdpi.com
Simple Summary Tumor cell invasiveness and metastasis are key processes in cancer
progression and are composed of many steps. All of them are regulated by multiple …

Downregulation of microRNA-1 and microRNA-145 contributes synergistically to the development of colon cancer

X Xu, X Wu, Q Jiang, Y Sun, H Liu… - International …, 2015 - spandidos-publications.com
The aim of the present study was to identify the differentially expressed microRNAs (miRNAs
or miRs) in patients with colon cancer and examine their roles in the pathogenesis of the …

MiR‐127‐3p inhibits cell growth and invasiveness by targeting ITGA6 in human osteosarcoma

D Wang, L Tang, H Wu, K Wang, D Gu - IUBMB life, 2018 - Wiley Online Library
Osteosarcoma (OS) is one of the most universal malignant bone tumors that occur mostly in
children and adolescents. This study aimed to investigate the roles of miR‐127‐3p and …

[HTML][HTML] Role of microRNA regulation in obesity-associated breast cancer: nutritional perspectives

R Kasiappan, D Rajarajan - Advances in Nutrition, 2017 - Elsevier
Breast cancer is the most common malignancy diagnosed in women, and the incidence of
breast cancer is increasing every year. Obesity has been identified as one of the major risk …