Blood–brain barrier link to human cognitive impairment and Alzheimer's disease

G Barisano, A Montagne, K Kisler… - Nature cardiovascular …, 2022 - nature.com
Vascular dysfunction is frequently observed in disorders associated with cognitive
impairment, dementia and Alzheimer's disease (AD). Recent advances in neuroimaging and …

Physiology and clinical relevance of enlarged perivascular spaces in the aging brain

CW Bown, RO Carare, MS Schrag, AL Jefferson - Neurology, 2022 - AAN Enterprises
Perivascular spaces (PVS) are fluid-filled compartments that are part of the cerebral blood
vessel wall and represent the conduit for fluid transport in and out of the brain. PVS are …

Association of enlarged perivascular spaces and measures of small vessel and Alzheimer disease

EC Gertje, D van Westen, C Panizo… - Neurology, 2021 - AAN Enterprises
Objective To investigate the relationship between enlarged perivascular spaces (EPVS) and
measures of Alzheimer disease (AD), small vessel disease (SVD), cognition, vascular risk …

Cognitive impairment caused by hypoxia: from clinical evidences to molecular mechanisms

X Wang, L Cui, X Ji - Metabolic Brain Disease, 2022 - Springer
Hypoxia is a state of reduced oxygen supply and excessive oxygen consumption. According
to the duration of hypoxic period, it can be classified as acute and chronic hypoxia. Both …

Volumetric distribution of perivascular space in relation to mild cognitive impairment

F Sepehrband, G Barisano, N Sheikh-Bahaei… - Neurobiology of …, 2021 - Elsevier
Vascular contributions to early cognitive decline are increasingly recognized, prompting
further investigation into the nature of related changes in perivascular spaces (PVS). Using …

The role of brain perivascular space burden in early-stage Parkinson's disease

T Shen, Y Yue, S Zhao, J Xie, Y Chen, J Tian… - NPJ Parkinson's …, 2021 - nature.com
Perivascular space (PVS) is associated with neurodegenerative diseases, while its effect on
Parkinson's disease (PD) remains unclear. We aimed to investigate the clinical and …

Why are perivascular spaces important?

T Shulyatnikova, MR Hayden - Medicina, 2023 - mdpi.com
Perivascular spaces (PVS) and their enlargement (EPVS) have been gaining interest as
EPVS can be visualized non-invasively by magnetic resonance imaging (MRI) when viewing …

Neuropathologic and cognitive correlates of enlarged perivascular spaces in a community-based cohort of older adults

C Javierre-Petit, JA Schneider, A Kapasi, N Makkinejad… - Stroke, 2020 - Am Heart Assoc
Background and Purpose: Enlarged perivascular spaces (EPVS) have been associated with
aging, increased stroke risk, decreased cognitive function, and vascular dementia. However …

Brain Injury: Response to Injury Wound-Healing Mechanisms and Enlarged Perivascular Spaces in Obesity, Metabolic Syndrome, and Type 2 Diabetes Mellitus

MR Hayden - Medicina, 2023 - mdpi.com
Embryonic genetic mechanisms are present in the brain and ready to be placed into action
upon cellular injury, termed the response to injury wound-healing (RTIWH) mechanism …

[HTML][HTML] Heterogeneity of white matter hyperintensities in cognitively impaired patients with cerebral small vessel disease

T Wang, A Jin, Y Fu, Z Zhang, S Li, D Wang… - Frontiers in …, 2021 - frontiersin.org
Objective Similar white matter hyperintensities (WMH) might have different impact on the
cognitive outcomes in patients with cerebral small vessel disease (CSVD). This study is to …