One of the most important issues facing cartilage tissue engineering is the inability to move
technologies into the clinic. Despite the multitude of current research in the field, it is known …

Articular cartilage injuries and degenerative joint diseases are responsible for progressive
pain and disability in millions of people worldwide, yet there is currently no treatment …

Articular cartilage repair and regeneration continue to be largely intractable because of the
poor regenerative properties of this tissue. The field of articular cartilage tissue engineering …

Skeletal regeneration is accomplished by a cascade of biologic processes that may include
differentiation of pluripotential tissue, endochondral ossification, and bone remodeling. It has …

When using hydrogel scaffolds for cartilage tissue engineering, two gel properties are
particularly important: the equilibrium water content (q, equilibrium swelling ratio) and the …

▪ Abstract Recent studies suggest that there are multiple regulatory pathways by which
chondrocytes in articular cartilage sense and respond to mechanical stimuli, including …

Mechanical loads induce changes in the structure, composition, and function of living
tissues. Cells in tissues are responsible for these changes, which cause physiological or …

Primary open angle glaucoma is a common eye disease characterized by loss of the axons
of the retinal ganglion cells leading to progressive loss of vision. The site of damage to the …

The composition and organisation of the extracellular matrix (ECM), particularly the
pericellular matrix (PCM), in articular cartilage is critical to its biomechanical functionality; the …

The histomorphogenesis of articular cartilage is regulated during skeletal development by
the intermittent forces and motions imposed at diarthrodial joints. A key feature in this …