Introduction: Central sensitization is a form of maladaptive neuroplasticity underlying many
chronic pain disorders, including neuropathic pain, fibromyalgia, whiplash, headache …

Chronic pain is sustained, in part, through the intricate process of central sensitization (CS),
marked by maladaptive neuroplasticity and neuronal hyperexcitability within central pain …

In the past 20 years, nerve growth factor (NGF) and its receptors TrkA & p75NTR were
recognized to be overexpressed in the overwhelming majority of human solid cancers …

Cancer-induced bone pain (CIBP) is a type of ongoing or breakthrough pain caused by a
primary bone tumor or bone metastasis. CIBP constitutes a specific pain state with distinct …

1. Background Quality of life of patients with head and neck cancer (HNC) is notoriously
poor because of the greater prevalence of pain compared with other cancer types. 15, 42 …

Many common cancers have a propensity to metastasize to bone. Although malignancies
often go undetected in their native tissues, bone metastases produce excruciating pain that …

The majority of patients with oral cancer report intense pain that is only partially managed by
current analgesics. Thus, there is a strong need to study mechanisms as well as develop …

Brain derived neurotrophic factor (BDNF) is a neurotrophin, expressed in the central nervous
system and in peripheral tissues, that is regulated by the Gsα/cAMP pathway. In bone, it …

Background Postherpetic neuralgia (PHN) is a devastating complication after varicella-
zoster virus infection. Brain-derived neurotrophic factor (BDNF) has been shown to …

Skeletal metastases are frequently accompanied by chronic pain that is mechanoceptive in
nature. Mechanistically, cancer-induced bone pain (CIBP) is mediated by peripheral sensory …