On the 100 th anniversary of Alzheimer's lecture describing the clinicopathological entity
which bears his eponym, this article reviews the major areas of progress in our …

The cloning of APP and genetic analysis of families with Alzheimer's disease were both
reported in 1987 and much present work on the disease is based upon the foundations laid …

To determine whether neurodegeneration in Alzheimer disease brain is associated with
degradation of structural cell membrane molecules, we measured tissue levels of the major …

In patients with Alzheimer's disease, amyloid fibrils that are aggregates of A4 protein
subunits are deposited in the brain. A similar process occurs at an earlier age in persons …

ALZHEIMER'S disease is the most common cause of progressive intellectual failure in aged
humans. The filamentous brain lesions which define the disease occur within neurons …

Alzheimer's disease1 is characterized by cerebral deposits of amyloid β-protein (AP) as
senile plaque core and vascular amyloid2–6, and a complementary DNA encoding a …

The amyloid proteins isolated from neuritic plaques and the cerebrovasculature of
Alzheimer's disease are self-aggregating moieties termed A4 protein1 and βprotein2, 3 …

The histologic diagnosis of Alzheimer's disease (AD) might be aided if a more sensitive
marker of aberrant A4 amyloid protein deposition were available. We screened a sample of …

The mouse brain contains genetically distinct cells that differ with respect to chromosome
number manifested as aneuploidy (Rehen et al., 2001); however, the relevance to humans …

The β-amyloid protein is progressively deposited in Alzheimer's disease as vascular amyloid
and as the amyloid cores of neuritic plaques. Contrary to its metabolically inert appearance …