Cancer cells employ both conventional oxidative metabolism and glycolytic anaerobic
metabolism. However, their proliferation is marked by a shift towards increasing glycolytic …

Cell cycle progression and division is regulated by checkpoint controls and sequential
activation of cyclin-dependent kinases (CDKs). Understanding of how these events occur in …

NSCLC is the leading cause of cancer mortality and represents a major challenge in cancer
therapy. Intrinsic and acquired anticancer drug resistance are promoted by hypoxia and HIF …

Citrate plays a central role in cancer cells' metabolism and regulation. Derived from
mitochondrial synthesis and/or carboxylation of α-ketoglutarate, it is cleaved by ATP-citrate …

Cancer metabolism is emerging as a chemotherapeutic target. Enhanced glycolysis and
suppression of mitochondrial metabolism characterize the Warburg phenotype in cancer …

The multikinase inhibitor sorafenib, and opening of voltage dependent anion channels
(VDAC) by the erastin-like compound X1 promotes oxidative stress and mitochondrial …

Upregulation of glycolysis, induction of epithelial–mesenchymal transition (EMT) and
macroautophagy (hereafter autophagy), are phenotypic changes that occur in tumor cells, in …

Hepatocellular carcinoma (HCC) represents the third cause of cancer death in men
worldwide, and its increasing incidence can be explained by the increasing occurrence of …

Genetic alterations drive tumor onset and progression. However, the cross‑talk between
tumor cells and the benign components of the surrounding stroma can also promote the …

Reprogramming energy production from mitochondrial respiration to glycolysis is now
considered a hallmark of cancer. When tumors grow beyond a certain size they give rise to …