Pulmonary hypertension is a life-threatening disease with no known cure. Here we provide a
concise yet comprehensive review of the current knowledge about the pathophysiology of …

The dietary consumption of fructose has increased in the last five decades, paralleled by an
increase in obesity. Excess fructose intake is linked to obesity, metabolic syndrome, non …

Pyruvate kinase isoenzyme M2 (PKM2) has previously been identified as a tumor biomarker
and as a potential target for cancer therapy. In this study, F § FJ‑5, a characterized …

Metabolic rewiring and deregulation of the cell cycle are hallmarks shared by many cancers.
Concerted mutations in key tumor suppressor genes, such as PTEN, and oncogenes …

The Warburg phenotype is characterized by enhanced glycolysis and suppression of
mitochondrial metabolism. Sustained glycolysis depends on a low cytosolic ATP/ADP ratio …

The contribution of mitochondria to cancer cell metabolism is a continuously growing
research field. Enhanced glycolysis and partial suppression of mitochondrial metabolism …

We present a formal model of the regulation of the energetic metabolism in eukaryotic cells.
The main originality of this model is to consider explicitly an abstraction of the main …

Résumé Nous présentons une modélisation formelle de la régulation du métabolisme
énergétique de la cellule eucaryote. Le choix original de cette modélisation est de …

Agent-based models have attracted the interest of cancer researchers thanks to their ability
to simulate months worth of tumour growth in a matter of hours, significantly reduced costs …

Cancer cells display an atypical metabolic phenotype that is characterized by high rates of
glycolysis and lactate fermentation in the presence of sufficient oxygen. This phenomenon …