Protein phosphorylation, one of the main protein post-translational modifications, is required
for regulating various life activities. Kinases and phosphatases that regulate protein …

Technologies are transforming the understanding of adipose tissue as a complex and
dynamic tissue that plays a critical role in energy homoeostasis and metabolic health. This …

Hsp90 is an essential molecular chaperone responsible for the folding and activation of
hundreds of 'client'proteins, including the glucocorticoid receptor (GR). Previously, we …

Advancements in mass spectrometry (MS)-based proteomics have greatly facilitated the
large-scale quantification of proteins and microproteins, thereby revealing altered signalling …

Post-translational modifications (PTMs) have key roles in extending the functional diversity
of proteins and, as a result, regulating diverse cellular processes in prokaryotic and …

INTRODUCTION Experimental models are essential tools in neurodegenerative disease
research. However, the translation of insights and drugs discovered in model systems has …

Small ubiquitin-like modifiers (SUMOs) are tiny but important protein regulators involved in
orchestrating a broad spectrum of biological processes, either by covalently modifying …

Liver cancer is ranked as the sixth most prevalent from of malignancy globally and stands as
the third primary contributor to cancer-related mortality. Metastasis is the main reason for …

Background Protein farnesylation involves the addition of a 15-carbon polyunsaturated
farnesyl group to proteins whose C-terminus ends with a CaaX motif. This post-translational …

Protein phosphorylation is a dynamic and reversible post‐translational modification that
regulates a variety of essential biological processes. The regulatory role of phosphorylation …