Fibrosis, defined by the excess deposition of structural and matricellular proteins in the
extracellular space, underlies tissue dysfunction in multiple chronic diseases. Approved …

Diffuse myocardial fibrosis resulting from the excessive deposition of collagen fibres through
the entire myocardium is encountered in a number of chronic cardiac diseases. This lesion …

Asthma is an inflammatory disease of the airways that may result from exposure to allergens
or other environmental irritants, resulting in bronchoconstriction, wheezing, and shortness of …

Rationale: Idiopathic pulmonary fibrosis (IPF) is an insidious and fatal interstitial lung
disease associated with declining pulmonary function. Accelerated aging, loss of epithelial …

The extracellular matrix (ECM) is a complex network of macromolecules surrounding cells
providing structural support and stability to tissues. The understanding of the ECM and the …

Fibrosis is the final hallmark of pathological remodeling, which is a major contributor to the
pathogenesis of various chronic diseases and aging-related organ failure to fully control …

Fibrosis is the abnormal accumulation of extracellular matrix proteins such as collagen and
fibronectin. Aging, injury, infections, and inflammation can cause different types of tissue …

Cancer immunotherapy has become a well-established treatment option for some cancers;
however, its use is hampered by its cardiovascular adverse effects. Immune checkpoint …

The systemic metabolic shifts that occur during aging and the local metabolic alterations of a
tumor, its stroma and their communication cooperate to establish a unique tumor …

The lungs face ongoing chemical, mechanical, biological, immunological and xenobiotic
stresses over a lifetime. Advancing age progressively impairs lung function. Autophagy is a …